(R)-phenylglycine amide

Base Information

• Chemical Name: (R)-phenylglycine amide
• CAS No.: 58429-87-1
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Mol file: 58429-87-1.mol

Synonyms:

Chemical Property of (R)-phenylglycine amide

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-phenylglycine amide

There total 39 articles about (R)-phenylglycine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C23H20N2O → (R)-phenylglycine amide (700-63-0,6485-52-5,6485-67-2,58429-87-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h; under 760.051 Torr;

DOI:10.1021/acscatal.9b02739

Reference yield: 96.0%

D-phenylglycine methyl ester hydrochloride (19883-41-1,13226-98-7) → (R)-phenylglycine amide (700-63-0,6485-52-5,6485-67-2,58429-87-1)

Guidance literature:

With ammonia; water; In toluene;

DOI:10.1039/c2ob25472g

Reference yield: 95.1%

(R)-phenylglycine nitrile (45789-64-8) → (R)-phenylglycine amide (700-63-0,6485-52-5,6485-67-2,58429-87-1)

Guidance literature:

With sulfuric acid; In aq. phosphate buffer; at 5 ℃; for 22h; pH=7; Reagent/catalyst; Temperature; Time; pH-value; Catalytic behavior; Enzymatic reaction;

DOI:10.1021/op000055l

upstream raw materials:

Phenylglycinamid

(R)-Phenylglycine methyl ester

(RS)-phenylglycinamide hydrochloride

D-phenylglycine methyl ester hydrochloride

Downstream raw materials:

(R)-2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-2-phenyl-acetamide

D-phenylglycyl-L-phenylglycine

D-phenylglycyl-L-isoleucine

(2R)-2-{[(E)-(1,1'-biphenyl)-2-ylmethylidene]amino}-2-phenylethanamide

Refernces

• 1、 Lin, Jian Bin,Dasgupta, Debarshi,Cantekin, Seda,Schenning, Albertus P. H. J.. "Towards racemizable chiral organogelators". . p. 960 - 965. Retrieved 2010.
• 2、 -. "COMPLEMENT MODULATORS AND RELATED METHODS". Paragraph 0422. . Retrieved 2020/10/20.
• 3、 Kawahara, Nobuhiro,Asano, Yasuhisa. "RETRACTED ARTICLE: Chemoenzymatic Method for Enantioselective Synthesis of (R)-2-Phenylglycine and (R)-2-Phenylglycine Amide from Benzaldehyde and KCN Using Difference of Enzyme Affinity to the Enantiomers". . p. 5014 - 5020. Retrieved 2018/10/20.