C₂₀H₂₁N₂OF₃

Base Information

• Chemical Name: C₂₀H₂₁N₂OF₃
• CAS No.: 948853-57-4
• Molecular Formula: C₂₀H₂₁F₃N₂O
• Molecular Weight: 362.395
• Mol file: 948853-57-4.mol

Synonyms:

Chemical Property of C₂₀H₂₁N₂OF₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₁N₂OF₃

There total 2 articles about C₂₀H₂₁N₂OF₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidin-4-one (41661-47-6) → C20H21N2OF3 (948853-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NEt₃ / CH₂Cl₂

2: NaBH(OAc)3; AcOH; molecular sieves / 1,2-dichloro-ethane

With molecular sieve; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2007.05.035

Reference yield:

1-(2,6-difluorobenzoyl)piperidin-4-one (948853-53-0) + 4-fluoro-2-phenethylamine (1583-88-6) → C20H21N2OF3 (948853-57-4)

Guidance literature:

With molecular sieve; sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2007.05.035

Reference yield:

C20H21N2OF3 (948853-57-4) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(4-fluorophenyl)-1,5-dimethyl-1,2-dihydro-3H-pyrazol-3-one (5400-60-2) → C32H32N4O2F4

Guidance literature:

With ammonium chloride; In isopropyl alcohol; at 90 ℃;

DOI:10.1016/j.bmcl.2007.05.035

upstream raw materials:

1-(2,6-difluorobenzoyl)piperidin-4-one

4-fluoro-2-phenethylamine

piperidin-4-one

Refernces