Technology Process of 2′,4′,5′,7′-tetrafluoro-3′,6′-dihydroxy-5,10-diphenyl-3H-spiro-[anthra[2,3-c]furan-1,9′-xanthen]-3-one
There total 4 articles about 2′,4′,5′,7′-tetrafluoro-3′,6′-dihydroxy-5,10-diphenyl-3H-spiro-[anthra[2,3-c]furan-1,9′-xanthen]-3-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate / water; dichloromethane / 5 - 7 °C / Inert atmosphere
2: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; pyridine / ethyl acetate / 2.5 h / 0 - 5 °C / Inert atmosphere
3: tetrahydrofuran / 2 h / -18 - -2 °C / Inert atmosphere
With
pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo500089t
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride; sodium nitrite; hypophosphorous acid / water / 0 - 5 °C / Inert atmosphere
2.1: dichloromethane / 20 °C / Inert atmosphere
2.2: 48 h / 20 °C
3.1: methanesulfonic acid / 24 h / 150 °C / Inert atmosphere; Darkness
With
hydrogenchloride; hypophosphorous acid; sodium nitrite;
In
methanesulfonic acid; dichloromethane; water;
DOI:10.1021/jo500219y
- Guidance literature:
-
In
methanesulfonic acid;
at 150 ℃;
for 24h;
Inert atmosphere;
Darkness;
DOI:10.1021/jo500219y