Technology Process of Trifluoro-acetic acid (S)-1-((S)-3-phenyl-butyl)-1-(2,2,2-trifluoro-acetoxymethyl)-decyl ester
There total 9 articles about Trifluoro-acetic acid (S)-1-((S)-3-phenyl-butyl)-1-(2,2,2-trifluoro-acetoxymethyl)-decyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 80 percent / BuLi
2: 58 percent / DMSO, (CF3CO)2O, Et3N
3: tetrahydrofuran; diethyl ether
4: 1.) NCS, AgNO3, 2.) NaBH4
5: CDCl3
With
sodium tetrahydroborate; N-chloro-succinimide; n-butyllithium; silver nitrate; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride;
In
tetrahydrofuran; diethyl ether; chloroform-d1;
DOI:10.1021/jo00177a047
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 99 percent / LiAlH4 / diethyl ether
2: 89 percent / Ph3PBr2 / dimethylformamide
3: Mg / diethyl ether / sonication
4: tetrahydrofuran; diethyl ether
5: 1.) NCS, AgNO3, 2.) NaBH4
6: CDCl3
With
sodium tetrahydroborate; N-chloro-succinimide; lithium aluminium tetrahydride; silver nitrate; magnesium; triphenylphosphine dibromide 1:1 addition complex;
In
tetrahydrofuran; diethyl ether; chloroform-d1; N,N-dimethyl-formamide;
DOI:10.1021/jo00177a047
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 89 percent / Ph3PBr2 / dimethylformamide
2: Mg / diethyl ether / sonication
3: tetrahydrofuran; diethyl ether
4: 1.) NCS, AgNO3, 2.) NaBH4
5: CDCl3
With
sodium tetrahydroborate; N-chloro-succinimide; silver nitrate; magnesium; triphenylphosphine dibromide 1:1 addition complex;
In
tetrahydrofuran; diethyl ether; chloroform-d1; N,N-dimethyl-formamide;
DOI:10.1021/jo00177a047