5-p-tolyloxymethyl-[1,3,4]oxadiazol-2-ylamine

Base Information

• Chemical Name: 5-p-tolyloxymethyl-[1,3,4]oxadiazol-2-ylamine
• CAS No.: 21826-03-9
• Molecular Formula: C₁₀H₁₁N₃O₂
• Molecular Weight: 205.216
• Mol file: 21826-03-9.mol

Synonyms:

Chemical Property of 5-p-tolyloxymethyl-[1,3,4]oxadiazol-2-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-p-tolyloxymethyl-[1,3,4]oxadiazol-2-ylamine

There total 2 articles about 5-p-tolyloxymethyl-[1,3,4]oxadiazol-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-methylphenoxy)acetic acid (940-64-7) + semicarbazide hydrochloride (563-41-7) → 5-p-tolyloxymethyl-[1,3,4]oxadiazol-2-ylamine (21826-03-9)

Guidance literature:

With sulfuric acid; at 60 - 80 ℃; for 4h; Yield given;

DOI:10.1002/ardp.19833160913

Reference yield:

bromocyane (506-68-3) + 4-methylphenoxyacetyl hydrazide (36304-39-9) → 5-p-tolyloxymethyl-[1,3,4]oxadiazol-2-ylamine (21826-03-9)

Guidance literature:

With potassium hydrogencarbonate; In methanol;

DOI:10.1002/ardp.19683011205

Reference yield:

5-p-tolyloxymethyl-[1,3,4]oxadiazol-2-ylamine (21826-03-9) → 5-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-(5-p-tolyloxymethyl-[1,3,4]oxadiazol-2-yl)-imidazolidine-2,4-dione (87658-21-7)

Guidance literature:

Multi-step reaction with 3 steps

1: glacial acetic acid / H₂O / 1.5 h / Ambient temperature

2: pyridine

3: acetic anhydride, CH₃COONa / acetic acid / 8 h / 140 - 150 °C

With sodium acetate; acetic anhydride; acetic acid; In pyridine; water; acetic acid;

DOI:10.1002/ardp.19833160913

upstream raw materials:

bromocyane

4-methylphenoxyacetyl hydrazide

2-(4-methylphenoxy)acetic acid

semicarbazide hydrochloride

Downstream raw materials:

(5-p-Tolyloxymethyl-[1,3,4]oxadiazol-2-yl)-urea

1-(5-p-Tolyloxymethyl-[1,3,4]oxadiazol-2-yl)-imidazolidine-2,4-dione

5-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-1-(5-p-tolyloxymethyl-[1,3,4]oxadiazol-2-yl)-imidazolidine-2,4-dione

5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-1-(5-p-tolyloxymethyl-[1,3,4]oxadiazol-2-yl)-imidazolidine-2,4-dione

Refernces

• 1、 Gehlen,Uteg. "On knowledge of 2-amino-1,3,4-oxidazole. 25. 2-amino-5-aryloxy(thio)alkyl-1,3,4-oxdiazole". . p. 911 - 922. Retrieved 2007/10/06.