methyl 4,4-dimethoxybutylcarbamate

Base Information

• Chemical Name: methyl 4,4-dimethoxybutylcarbamate
• CAS No.: 99903-96-5
• Molecular Formula: C₈H₁₇NO₄
• Molecular Weight: 191.227
• Mol file: 99903-96-5.mol

Synonyms:

Chemical Property of methyl 4,4-dimethoxybutylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4,4-dimethoxybutylcarbamate

There total 8 articles about methyl 4,4-dimethoxybutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

methanol (67-56-1) + 1-(mesyloxy)-3-methoxypiperidin-2-one (1259429-07-6) → methyl 4,4-dimethoxybutylcarbamate (99903-96-5) + methyl 2-methoxypyrrolidine-1-carboxylate (56475-88-8)

Guidance literature:

1-(mesyloxy)-3-methoxypiperidin-2-one; In dichloromethane; at -78 ℃; for 1.5h; UV-irradiation; Inert atmosphere;

methanol; With triethylamine; In dichloromethane; for 16h; Inert atmosphere;

DOI:10.1021/jo101805q

Reference yield: 65.0%

methanol (67-56-1) + 1-(mesyloxy)-3-acetoxypiperidin-2-one (1259429-10-1) → methyl 4,4-dimethoxybutylcarbamate (99903-96-5) + methyl 2-methoxypyrrolidine-1-carboxylate (56475-88-8)

Guidance literature:

With triethylamine; at -78 ℃; for 3.5h; UV-irradiation; Inert atmosphere;

DOI:10.1021/jo101805q

Reference yield: 51.0%

methanol (67-56-1) + 1-chloro-3-methoxypiperidin-2-one (1215765-13-1) → 3-methoxy-piperidin-2-one (25219-59-4) + methyl 4,4-dimethoxybutylcarbamate (99903-96-5) + methyl 2-methoxypyrrolidine-1-carboxylate (56475-88-8)

Guidance literature:

1-chloro-3-methoxypiperidin-2-one; In dichloromethane; at -78 ℃; for 4.5h; UV-irradiation; Inert atmosphere;

methanol; With potassium carbonate; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jo100181h

upstream raw materials:

methanol

1-chloro-3-methoxypiperidin-2-one

3,4,5,6-tetrahydro-2H-pyran-2-one

1-(mesyloxy)-3-methoxypiperidin-2-one

Downstream raw materials:

4-aminobutyraldehyde dimethyl acetal

Refernces

• 1、 Winter, Dana K.,Drouin, Alexandre,Lessard, Jean,Spino, Claude. "Photochemical rearrangement of N -chlorolactams: A route to N -heterocycles through concerted ring contraction". supporting information; experimental part. p. 2610 - 2618. Retrieved 2010/06/17.