3-Methoxy-2-Piperidone

Base Information

• Chemical Name: 3-Methoxy-2-Piperidone
• CAS No.: 25219-59-4
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.16
• Hs Code.: 2933790090
• Mol file: 25219-59-4.mol

Synonyms:2-Piperidone,3-methoxy- (8CI);

Chemical Property of 3-Methoxy-2-Piperidone

Chemical Property:

• Vapor Pressure: 0.00389mmHg at 25°C
• Refractive Index: 1.461
• Boiling Point: 279.963 °C at 760 mmHg
• PKA: 15.54±0.40(Predicted)
• Flash Point: 123.118 °C
• PSA: 38.33000
• Density: 1.067 g/cm³
• LogP: 0.24020
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methoxypiperidin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Methoxypiperidin-2-one is a useful research chemical.

Technology Process of 3-Methoxy-2-Piperidone

There total 7 articles about 3-Methoxy-2-Piperidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methanol (67-56-1) + 3-diazo-piperidin-2-one (463362-69-8) → 3-methoxy-piperidin-2-one (25219-59-4)

Guidance literature:

dirhodium tetraacetate; at 25 ℃; for 1h;

DOI:10.1016/S0040-4020(02)00278-8

Reference yield: 51.0%

methanol (67-56-1) + 1-chloro-3-methoxypiperidin-2-one (1215765-13-1) → 3-methoxy-piperidin-2-one (25219-59-4) + methyl 4,4-dimethoxybutylcarbamate (99903-96-5) + methyl 2-methoxypyrrolidine-1-carboxylate (56475-88-8)

Guidance literature:

1-chloro-3-methoxypiperidin-2-one; In dichloromethane; at -78 ℃; for 4.5h; UV-irradiation; Inert atmosphere;

methanol; With potassium carbonate; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jo100181h

Reference yield:

3-aminopiperidin-2-one (1892-22-4,4077-38-7,34294-79-6,88763-76-2) → 3-methoxy-piperidin-2-one (25219-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / iso-amyl nitrite; glacoal AcOH / CHCl₃ / 0.25 h / Heating

2: 82 percent / Rh₂(OAc)4 / 1 h / 25 °C

With acetic acid; isopentyl nitrite; dirhodium tetraacetate; In chloroform;

DOI:10.1016/S0040-4020(02)00278-8

upstream raw materials:

methanol

3-diazo-piperidin-2-one

3-aminopiperidin-2-one

L-ornithine hydrochloride

Refernces

• 1、 Winter, Dana K.,Drouin, Alexandre,Lessard, Jean,Spino, Claude. "Photochemical rearrangement of N -chlorolactams: A route to N -heterocycles through concerted ring contraction". supporting information; experimental part. p. 2610 - 2618. Retrieved 2010/06/17.