1-benzenesulfonyl-17-methoxy-16ζ,17-2α,7α-tetrahydrocorynantheidine

Base Information

• Chemical Name: 1-benzenesulfonyl-17-methoxy-16ζ,17-2α,7α-tetrahydrocorynantheidine
• CAS No.: 82503-78-4
• Molecular Formula: C₂₉H₃₈N₂O₆S
• Molecular Weight: 542.697
• Mol file: 82503-78-4.mol

Synonyms:

Chemical Property of 1-benzenesulfonyl-17-methoxy-16ζ,17-2α,7α-tetrahydrocorynantheidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzenesulfonyl-17-methoxy-16ζ,17-2α,7α-tetrahydrocorynantheidine

There total 3 articles about 1-benzenesulfonyl-17-methoxy-16ζ,17-2α,7α-tetrahydrocorynantheidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dihydro-2α,7α corynantheidine (82503-71-7) → 1-benzenesulfonyl-17-methoxy-16ζ,17-2α,7α-tetrahydrocorynantheidine (82503-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 509 mg / NaOMe / methanol / 12 h / 50 °C

2: pyridine

With pyridine; sodium methylate; In methanol;

DOI:10.1016/0040-4020(82)80007-0

Reference yield:

methyl (E)-2-((2S,3S,12bS)-3-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate (23407-35-4) → 1-benzenesulfonyl-17-methoxy-16ζ,17-2α,7α-tetrahydrocorynantheidine (82503-78-4)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄ / trifluoroacetic acid / 4 h / Ambient temperature

2: 509 mg / NaOMe / methanol / 12 h / 50 °C

3: pyridine

With pyridine; sodium tetrahydroborate; sodium methylate; In methanol; trifluoroacetic acid;

DOI:10.1016/0040-4020(82)80007-0

Reference yield:

methoxy-17 tetrahydro-17ζ,17-2α,7α corynantheidine (82503-85-3) + benzenesulfonyl chloride (98-09-9) → 1-benzenesulfonyl-17-methoxy-16ζ,17-2α,7α-tetrahydrocorynantheidine (82503-78-4)

Guidance literature:

With pyridine;

DOI:10.1016/0040-4020(82)80007-0

upstream raw materials:

methoxy-17 tetrahydro-17ζ,17-2α,7α corynantheidine

benzenesulfonyl chloride

dihydro-2α,7α corynantheidine

methyl (E)-2-((2S,3S,12bS)-3-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate

Downstream raw materials:

(2S,3S)-12-Benzenesulfonyl-3-ethyl-1,3,4,7,7a,12,12a,12b-octahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizine-13-carbaldehyde

1-benzene-sulfonyl-2α,7α-20α,19-tetrahydro-10-deoxysarpagine

1-benzenesulfonyl-17-methoxy-5α-cyano-16ζ,17-2α,7α-tetrahydrocorynantheidine

Refernces