1-(2-hydroxyethyl)-2-(4-fluorophenyl)-5-nitroimidazole acetate

Base Information

• Chemical Name: 1-(2-hydroxyethyl)-2-(4-fluorophenyl)-5-nitroimidazole acetate
• CAS No.: 59608-63-8
• Molecular Formula: C₁₃H₁₂FN₃O₄
• Molecular Weight: 293.254
• Mol file: 59608-63-8.mol

Synonyms:

Chemical Property of 1-(2-hydroxyethyl)-2-(4-fluorophenyl)-5-nitroimidazole acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-hydroxyethyl)-2-(4-fluorophenyl)-5-nitroimidazole acetate

There total 2 articles about 1-(2-hydroxyethyl)-2-(4-fluorophenyl)-5-nitroimidazole acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

3,4,5-triacetoxybenzoyl chloride (70475-59-1) + 2-(p-fluorophenyl)-1-(2'-hydroxyethyl)-5-nitroimidazole (4548-15-6) → 2-[2-(4-fluorophenyl)-5-nitroimidazol-1-yl]ethyl 3,4,5-triacetoxybenzoate (104575-35-1) + 1-(2-hydroxyethyl)-2-(4-fluorophenyl)-5-nitroimidazole acetate (59608-63-8)

Guidance literature:

With 4-pyrrolidin-1-ylpyridine; triethylamine; In dichloromethane; for 2.5h; Ambient temperature;

DOI:10.1021/jm00384a025

Reference yield:

→ 1-(2-hydroxyethyl)-2-(4-fluorophenyl)-5-nitroimidazole acetate (59608-63-8)

Guidance literature:

4-Nitroimidazol 3a, 1.)2-Methyl-1,3-dioxoleniumtetrafluoroborat (aus 2-Ethoxy-2-methyl-1,3-dioxolan u. BF3-Etherat), 2.)Pyridin;

DOI:10.1021/jm00251a020

upstream raw materials:

3,4,5-triacetoxybenzoyl chloride

2-(p-fluorophenyl)-1-(2'-hydroxyethyl)-5-nitroimidazole

Refernces

• 1、 Grabowski,Liu,Salce,Schoenewaldt. "An efficient and selective method for the synthesis of 2 (4 fluorophenyl) 1 (2 hydroxyethyl) 5 nitroimidazole (Flunidazole)". . p. 547 - 549. Retrieved 2007/10/09.