Quinoline, 4-(bromomethyl)-2-chloro-

Base Information

• Chemical Name: Quinoline, 4-(bromomethyl)-2-chloro-
• CAS No.: 137354-54-2
• Molecular Formula: C10H7BrClN
• Molecular Weight: 256.529
• Mol file: 137354-54-2.mol

Synonyms:

Chemical Property of Quinoline, 4-(bromomethyl)-2-chloro-

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinoline, 4-(bromomethyl)-2-chloro-

There total 1 articles about Quinoline, 4-(bromomethyl)-2-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromomethyl-2(1H)-quinolinone (4876-10-2) → 4-chloromethyl-2-chloroquinoline (20151-11-5) + 4-(bromomethyl)-2-chloroquinoline (137354-54-2)

Guidance literature:

With trichlorophosphate; at 80 - 90 ℃; for 0.666667h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1248/cpb.39.2906

Reference yield:

4-(bromomethyl)-2-chloroquinoline (137354-54-2) → 4-quinolylmethanol (6281-32-9)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium acetate; acetic acid

2: sodium acetate / 130 °C

3: phosphoryl chloride

4: potassium carbonate; water; ethanol

5: palladium; methanol; NaOH-solution / Hydrogenation

With methanol; sodium hydroxide; ethanol; water; sodium acetate; potassium carbonate; palladium; acetic acid; trichlorophosphate;

Reference yield:

4-(bromomethyl)-2-chloroquinoline (137354-54-2) + 2,4-Dimethoxybenzylamine (20781-20-8) + (3R)-3-fluoropyrrolidine hydrochloride (136725-53-6,169750-17-8,136725-55-8) → (R)-N-(2,4-dimethoxybenzyl)-4-((3-fluoropyrrolidin-1-yl)methyl)quinolin-2-amine

Guidance literature:

With sodium iodide; potassium carbonate; In water; N,N-dimethyl-formamide;

upstream raw materials:

4-bromomethyl-2(1H)-quinolinone

Downstream raw materials:

2-hydroxy-4-bromomethylquinoline

4-chloromethyl-2-chloroquinoline

4-quinolylmethanol

4-(chloromethyl)quinoline

Refernces