Technology Process of (2R,3S)-methyl 2-{(R)-3-[4-(benzyloxy)phenyl]-2-[(triisopropylsilyl)oxy]propanamido}-3-methylpentanoate
There total 5 articles about (2R,3S)-methyl 2-{(R)-3-[4-(benzyloxy)phenyl]-2-[(triisopropylsilyl)oxy]propanamido}-3-methylpentanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C25H36O4Si;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.333333h;
Inert atmosphere;
D-allo-isoleucine methyl ester;
With
triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 40h;
Inert atmosphere;
DOI:10.1021/ja309947n
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid; triethylsilane / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
2.1: dmap; 1H-imidazole / dichloromethane / 24 h / 20 °C / Inert atmosphere
3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere
4.2: 40 h / 20 °C / Inert atmosphere
With
1H-imidazole; triethylsilane; dmap; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; trifluoroacetic acid; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja309947n
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dmap; 1H-imidazole / dichloromethane / 24 h / 20 °C / Inert atmosphere
2.1: water; lithium hydroxide / methanol; tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere
3.2: 40 h / 20 °C / Inert atmosphere
With
1H-imidazole; dmap; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja309947n
