Technology Process of 1-(4-methylpiperazine-1-yl)-N-(4-methyl-3-[(4-pyridin-3-yl-pyrimidin-2-yl)amino]phenyl)-2,3-dihydro-1H-indene-5-carboxamide
There total 6 articles about 1-(4-methylpiperazine-1-yl)-N-(4-methyl-3-[(4-pyridin-3-yl-pyrimidin-2-yl)amino]phenyl)-2,3-dihydro-1H-indene-5-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium tetrahydroborate; methanol / ethyl acetate; methanol / 2.5 h
2: thionyl chloride / dichloromethane / 3.25 h / Cooling with ice
3: potassium carbonate / acetonitrile / 60 °C
4: sodium hydroxide / 100 °C
5: thionyl chloride / Reflux
6: trimethylaluminum / toluene / 50 - 60 °C
With
methanol; sodium tetrahydroborate; thionyl chloride; trimethylaluminum; potassium carbonate; sodium hydroxide;
In
methanol; dichloromethane; ethyl acetate; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: N,N-dimethyl-formamide / 140 °C
2: sodium tetrahydroborate; methanol / ethyl acetate; methanol / 2.5 h
3: thionyl chloride / dichloromethane / 3.25 h / Cooling with ice
4: potassium carbonate / acetonitrile / 60 °C
5: sodium hydroxide / 100 °C
6: thionyl chloride / Reflux
7: trimethylaluminum / toluene / 50 - 60 °C
With
methanol; sodium tetrahydroborate; thionyl chloride; trimethylaluminum; potassium carbonate; sodium hydroxide;
In
methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydroxide / 100 °C
2: thionyl chloride / Reflux
3: trimethylaluminum / toluene / 50 - 60 °C
With
thionyl chloride; trimethylaluminum; sodium hydroxide;
In
toluene;