1-OXO-2,3-DIHYDRO-1H-INDENE-5-CARBONITRILE

Base Information

• Chemical Name: 1-OXO-2,3-DIHYDRO-1H-INDENE-5-CARBONITRILE
• CAS No.: 25724-79-2
• Molecular Formula: C₁₀H₇NO
• Molecular Weight: 157.172
• Hs Code.: 2926909090
• Mol file: 25724-79-2.mol

Synonyms:5-cyano-indanone;5-cyano-1-indanone;2,3-dihydro-1-oxo-1H-indene-5-carbonitrile;1-oxoindane-5-carbonitrile;1-OXO-2,3-DIHYDRO-1H-INDENE-5-CARBONITRILE;1-oxo-2,3-dihydro-1H-inden-5-carbonitrile;1-oxo-indan-5-carbonitrile;

Chemical Property of 1-OXO-2,3-DIHYDRO-1H-INDENE-5-CARBONITRILE

Chemical Property:

• Vapor Pressure: 0.000228mmHg at 25°C
• Melting Point: 128-130 °C
• Boiling Point: 325.6°Cat760mmHg
• Flash Point: 150.7°C
• PSA: 40.86000
• Density: 1.23g/cm³
• LogP: 1.68718
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

2,3-Dihydro-1-oxo-1H-indene-5-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-OXO-2,3-DIHYDRO-1H-INDENE-5-CARBONITRILE

There total 16 articles about 1-OXO-2,3-DIHYDRO-1H-INDENE-5-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-Bromo-1-indanone (34598-49-7) + dicyanozinc (557-21-1) → 5-cyano-1-indanone (25724-79-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

DOI:10.1021/jm9903242

Reference yield: 81.0%

zinc(II) cyanide (557-21-1) + 5-Bromo-1-indanone (34598-49-7) → 5-cyano-1-indanone (25724-79-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield: 78.0%

5-Bromo-1-indanone (34598-49-7) + copper(I) cyanide (544-92-3) → 5-cyano-1-indanone (25724-79-2)

Guidance literature:

In N,N-dimethyl-formamide; at 140 ℃; for 16h;

DOI:10.1021/ol0512942

upstream raw materials:

5-aminoindan-1-one

copper(I) cyanide

5-Bromo-1-indanone

dicyanozinc

Downstream raw materials:

USC-L₄₀₁

1-(4-methylpiperazine-1-yl)-N-(4-methyl-3-[(4-pyridin-3-yl-pyrimidin-2-yl)amino]phenyl)-2,3-dihydro-1H-indene-5-carboxamide

N-[3-(4,5'-bipyrimdine-2-ylamino)-4-methylphenyl]-1-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-indene-5-carboxamide

1-amino-2,3-dihydro-1H-indene-5-carbonitrile

Refernces

• 1、 -. "INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS". Page/Page column 128. . Retrieved 2021/09/11.
• 2、 -. "DIHYDROBENZOFURAN AND INDEN ANALOGS AS CARDIAC SARCOMERE INHIBITORS". Paragraph 0377. . Retrieved 2019/08/08.