PYR-TRP-OET

Base Information

• Chemical Name: PYR-TRP-OET
• CAS No.: 87694-58-4
• Molecular Formula: C₁₈H₂₁N₃O₄
• Molecular Weight: 343.382
• Mol file: 87694-58-4.mol

Synonyms:

Chemical Property of PYR-TRP-OET

Chemical Property:

• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

PYR-TRP-OET 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of PYR-TRP-OET

There total 5 articles about PYR-TRP-OET which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-carbobenzoxy-L-pyroglutamyl-L-tryptophan ethyl ester (87694-59-5) → L-pyroglutamyl-L-tryptophan ethyl ester (87694-58-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 2h; under 760 Torr; Ambient temperature;

Reference yield: 41.0%

L-tryptophan ethyl ester hydrochloride (2899-28-7,6519-67-1,61535-49-7,67557-18-0,68401-14-9) + L-Pyroglutamic acid (98-79-3) → L-pyroglutamyl-L-tryptophan ethyl ester (87694-58-4)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 16h; Ambient temperature;

Reference yield:

Cbz-L-pGlu-OH (32159-21-0) → L-pyroglutamyl-L-tryptophan ethyl ester (87694-58-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) triethylamine, ethyl chloroformate, 2.) triethylamine / 1.) THF, 0 deg C, 30 min, 2.) r.t., 3 h

2: 93 percent / H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature

With hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In methanol;

upstream raw materials:

N-carbobenzoxy-L-pyroglutamyl-L-tryptophan ethyl ester

L-tryptophan ethyl ester hydrochloride

L-Pyroglutamic acid

Cbz-L-pGlu-OH

Downstream raw materials:

L-pyroglutamyl-L-tryptophan

Refernces