2-(4-Methylpiperazin-1-yl)ethanamine

Base Information

• Chemical Name: 2-(4-Methylpiperazin-1-yl)ethanamine
• CAS No.: 934-98-5
• Molecular Formula: C7H17N3
• Molecular Weight: 143.232
• Hs Code.: 29339900
• European Community (EC) Number: 213-296-3
• UNII: Z79BOY08I2
• DSSTox Substance ID: DTXSID10239420
• Nikkaji Number: J298.525J
• Wikidata: Q27157656
• Mol file: 934-98-5.mol

Synonyms:934-98-5;2-(4-methylpiperazin-1-yl)ethanamine;2-(4-Methyl-piperazin-1-yl)-ethylamine;4-methyl-1-piperazineethanamine;1-Piperazineethanamine, 4-methyl-;4-Methylpiperazine-1-ethylamine;1-(2-Aminoethyl)-4-methylpiperazine;1-(2-Aminoethyl)-4-methyl-piperazine;2-(4-Methyl-1-piperazinyl)ethanamine;2-(4-methylpiperazin-1-yl)ethylamine;2-(4-methylpiperazin-1-yl)ethan-1-amine;2-(4-METHYL-1-PIPERAZINYL)ETHYLAMINE;C7H17N3;MFCD03701701;Z79BOY08I2;EINECS 213-296-3;1-Methyl-4-(2-aminoethyl)piperazine;1-(n-aminoethyl)-4-methyl piperazine;1-(2-aminoethyl)-4-methyl piperazine;UNII-Z79BOY08I2;SCHEMBL42017;SCHEMBL4480122;CHEBI:84290;DTXSID10239420;2(4-methylpiperazin-1-yl)ethylamine;STK500900;4-hydroxy-8-trifluoromethyl-quinoline;AKOS000201108;AB15815;CCG-358157;CS-W007512;LF-0565;2-(4-methylpiperazin-1-yl) ethylamine;2-(4-methylpiperazin-1-yl)-ethanamine;2-(4-methylpiperazin-1-yl)-ethylamine;2-(4-METHYLPIPERAZINO)ETHANAMINE;Piperazine 1-[2-aminoethyl]-4-methyl-;2-(4-Methyl-1-piperazinyl)ethanamine #;AM804573;Piperazine, 1-(2-aminoethyl)-4-methyl-;SY032261;2-(4-methyl-piperazine-1-yl)-ethyl amine;4-(2-AMINOETHYL)-1-METHYLPIPERAZINE;BB 0219909;FT-0648216;EN300-24106;2-(4-Methyl-1-piperazino)ethylamine Hydrochloride;A844616;A846010;J-506071;2-(4-Methyl-piperazin-1-yl)-ethylamine, AldrichCPR;Q27157656;F2187-2164;N'-allyl-N'-(benzenesulfonyl)benzohydrazide;2-(4-Methyl-1-piperazinyl)ethylamine

Chemical Property of 2-(4-Methylpiperazin-1-yl)ethanamine

Chemical Property:

• Vapor Pressure: 0.148mmHg at 25°C
• Refractive Index: 1.487
• Boiling Point: 215.4 °C at 760 mmHg
• PKA: 10.11±0.10(Predicted)
• Flash Point: 83.3 °C
• PSA: 32.50000
• Density: 0.956 g/cm³
• LogP: -0.23140
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Air Sensitive
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 143.142247555
• Heavy Atom Count: 10
• Complexity: 86.9

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4-Methylpiperazin-1-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCN(CC1)CCN
• Uses: 2-(4-Methylpiperazin-1-yl)ethanamine (cas# 934-98-5) is a useful research chemical. 1-(2-Aminoethyl)-4-methylpiperazine is used as pharmaceutical intermediate.

Technology Process of 2-(4-Methylpiperazin-1-yl)ethanamine

There total 9 articles about 2-(4-Methylpiperazin-1-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2-(N-methylpiperazin-4-yl)ethyl)-1H-isoindole-1,3(2H)-dione (4489-39-8) → 2-(4-methylpiperazin-1-yl)ethylamine (934-98-5)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 24h;

DOI:10.1016/j.bioorg.2021.105543

Reference yield: 99.0%

2-(4-methylpiperazin-1-yl)acetonitrile (874-77-1) → 2-(4-methylpiperazin-1-yl)ethylamine (934-98-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 24h; Ambient temperature;

DOI:10.1021/jm981098j

Reference yield:

1-methyl-4-prop-2-ynyl-piperazine (45813-02-3) → 2-(4-methylpiperazin-1-yl)ethylamine (934-98-5)

Guidance literature:

1-methyl-4-prop-2-ynyl-piperazine; With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 24h;

With sodium hydroxide; water; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.333333h;

upstream raw materials:

1-methyl-piperazine

2-(4-methylpiperazin-1-yl)acetonitrile

1-methyl-4-prop-2-ynyl-piperazine

2-bromoethylamine

Downstream raw materials:

C₃₀H₃₁F₃N₆O₂S

4-[(4-methoxyphenyl)amino]-N-[2-(4-methylpiperazin-1-yl)ethyl]benzamide

C₂₈H₂₉F₆N₉O

Refernces

• 1、 Tazarki, Helmi,Zeinyeh, Wael,Esvan, Yannick J.,Knapp, Stefan,Chatterjee, Deep,Schr?der, Martin,Joerger, Andreas C.,Khiari, Jameleddine,Josselin, Béatrice,Baratte, Blandine,Bach, Stéphane,Ruchaud, Sandrine,Anizon, Fabrice,Giraud, Francis,Moreau, Pascale. "New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis". . p. 304 - 317. Retrieved 2019/02/07.
• 2、 Dola, Vasantha Rao,Soni, Awakash,Agarwal, Pooja,Ahmad, Hafsa,Raju, Kanumuri Siva Rama,Rashid, Mamunur,Wahajuddin, Muhammad,Srivastava, Kumkum,Haq,Dwivedi,Puri,Katti. "Synthesis and evaluation of chirally defined side chain variants of 7-chloro-4-aminoquinoline to overcome drug resistance in malaria chemotherapy". . . Retrieved 2017/03/09.