Technology Process of Nps-Ile-Ser-Leu-OMe
There total 3 articles about Nps-Ile-Ser-Leu-OMe which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide;
In
chloroform;
1.) 0 deg C, 30 min, 2.) room temperature, 5 h;
- Guidance literature:
-
Multi-step reaction with 3 steps
2: 1.) hydrogen, 2.) 0.4N-hydrogene chloride in methanol / 1.) 10percent palladium-charcoal / 1.) 1percent acetic acid in methanol, 2.5 h, 2.) -15 deg C
3: 80 percent / dicyclohexylcarbodi-imide, N-hydroxysuccinimide / CHCl3 / 1.) 0 deg C, 30 min, 2.) room temperature, 5 h
With
hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
chloroform;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) hydrogen, 2.) 0.4N-hydrogene chloride in methanol / 1.) 10percent palladium-charcoal / 1.) 1percent acetic acid in methanol, 2.5 h, 2.) -15 deg C
2: 80 percent / dicyclohexylcarbodi-imide, N-hydroxysuccinimide / CHCl3 / 1.) 0 deg C, 30 min, 2.) room temperature, 5 h
With
hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
chloroform;