Technology Process of 32-(8-(6-(4-[18F]fluorobenzamido)hexanoyl)-8,9-dihydro-1H-dibenzo[b,f][1,2,3]triazolo-[4,5-d]azocin-1-yl)-5-oxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacontan-1-oic acid
There total 14 articles about 32-(8-(6-(4-[18F]fluorobenzamido)hexanoyl)-8,9-dihydro-1H-dibenzo[b,f][1,2,3]triazolo-[4,5-d]azocin-1-yl)-5-oxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacontan-1-oic acid which
guide to synthetic route it.
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synthetic route:
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1341223-27-5
32-(8-(6-(4-[18F]fluorobenzamido)hexanoyl)-8,9-dihydro-1H-dibenzo[b,f][1,2,3]triazolo-[4,5-d]azocin-1-yl)-5-oxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacontan-1-oic acid
- Guidance literature:
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Multi-step reaction with 4 steps
1: pyridinium hydrobromide perbromide; potassium tert-butylate
2: potassium carbonate / methanol / 20 °C
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 37 °C
4: N,N-dimethyl-formamide / 0.5 h / 37 °C
With
pyridinium hydrobromide perbromide; potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/ml200187j
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1341223-27-5
32-(8-(6-(4-[18F]fluorobenzamido)hexanoyl)-8,9-dihydro-1H-dibenzo[b,f][1,2,3]triazolo-[4,5-d]azocin-1-yl)-5-oxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacontan-1-oic acid
- Guidance literature:
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Multi-step reaction with 4 steps
1: water; sodium hydroxide
2: trimethylammonium hydroxide / water; acetonitrile / 0.08 h / 100 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 37 °C
4: N,N-dimethyl-formamide / 0.5 h / 37 °C
With
trimethylammonium hydroxide; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml200187j
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1341223-27-5
32-(8-(6-(4-[18F]fluorobenzamido)hexanoyl)-8,9-dihydro-1H-dibenzo[b,f][1,2,3]triazolo-[4,5-d]azocin-1-yl)-5-oxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacontan-1-oic acid
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / methanol / 20 °C
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 37 °C
3: N,N-dimethyl-formamide / 0.5 h / 37 °C
With
potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/ml200187j