hexacarbonyl[1-{3,6-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt

Base Information

• Chemical Name: hexacarbonyl[1-{3,6-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt
• CAS No.: 1412443-43-6
• Molecular Formula: C₂₆H₂₅Co₂F₂NO₁₀
• Molecular Weight: 667.468
• Mol file: 1412443-43-6.mol

Synonyms:

Chemical Property of hexacarbonyl[1-{3,6-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hexacarbonyl[1-{3,6-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt

There total 3 articles about hexacarbonyl[1-{3,6-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,6-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]benzaldehyde (1412443-27-6) → hexacarbonyl[1-{3,6-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt (1412443-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / 1 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: dichloromethane / 0.17 h / Inert atmosphere

With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane;

DOI:10.1016/j.tet.2012.08.087

Reference yield:

3,6-difluoro-2-hydroxybenzaldehyde (502762-92-7) → hexacarbonyl[1-{3,6-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt (1412443-43-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / 1 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

3.1: dichloromethane / 0.17 h / Inert atmosphere

With potassium carbonate; potassium iodide; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2012.08.087

Reference yield:

prenyl bromide (870-63-3) → hexacarbonyl[1-{3,6-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt (1412443-43-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / 1 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

3.1: dichloromethane / 0.17 h / Inert atmosphere

With potassium carbonate; potassium iodide; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2012.08.087

upstream raw materials:

3,6-difluoro-2-hydroxybenzaldehyde

3,6-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]benzaldehyde

prenyl bromide

Refernces