N-but-3-enyl-4-methyl-N-(5-nitrofuran-2-yl)benzenesulfonamide

Base Information

• Chemical Name: N-but-3-enyl-4-methyl-N-(5-nitrofuran-2-yl)benzenesulfonamide
• CAS No.: 208335-39-1
• Molecular Formula: C₁₅H₁₆N₂O₅S
• Molecular Weight: 336.368
• Mol file: 208335-39-1.mol

Synonyms:

Chemical Property of N-but-3-enyl-4-methyl-N-(5-nitrofuran-2-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-but-3-enyl-4-methyl-N-(5-nitrofuran-2-yl)benzenesulfonamide

There total 3 articles about N-but-3-enyl-4-methyl-N-(5-nitrofuran-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide (18303-04-3) → N-but-3-enyl-4-methyl-N-(5-nitrofuran-2-yl)benzenesulfonamide (208335-39-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / PPh₃, diethyl acetylenedicarboxylate / tetrahydrofuran / 3 h / Ambient temperature

2: 88 percent / TFA / CH₂Cl₂ / 12 h / Ambient temperature

3: 1.) NaH / 1.) THF, room temperature, 30 min, 2.) THF, room temperature, 3.5 h

With sodium hydride; triphenylphosphine; trifluoroacetic acid; acetylenedicarboxylic acid diethyl ester; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo980008f

Reference yield:

N-(but-3-en-1-yl)-N-(tert-butoxycarbonyl)-4-methylbenzenesulfonamide (208335-94-8) → N-but-3-enyl-4-methyl-N-(5-nitrofuran-2-yl)benzenesulfonamide (208335-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / TFA / CH₂Cl₂ / 12 h / Ambient temperature

2: 1.) NaH / 1.) THF, room temperature, 30 min, 2.) THF, room temperature, 3.5 h

With sodium hydride; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jo980008f

Reference yield:

2,5-dinitrofuran (826-03-9) + N-tosyl-3-butenylamine (10285-80-0) → N-but-3-enyl-4-methyl-N-(5-nitrofuran-2-yl)benzenesulfonamide (208335-39-1)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, room temperature, 30 min, 2.) THF, room temperature, 3.5 h;

DOI:10.1021/jo980008f

upstream raw materials:

2,5-dinitrofuran

N-tosyl-3-butenylamine

N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

N-(but-3-en-1-yl)-N-(tert-butoxycarbonyl)-4-methylbenzenesulfonamide

Refernces