(+/-)-DOF

Base Information

• Chemical Name: (+/-)-DOF
• CAS No.: 125903-69-7
• Molecular Formula: C₁₁H₁₆FNO₂
• Molecular Weight: 213.252
• Mol file: 125903-69-7.mol

Synonyms:

Chemical Property of (+/-)-DOF

Chemical Property:

• Boiling Point: 294.8±35.0 °C(Predicted)
• Density: 1.093±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+/-)-DOF

There total 4 articles about (+/-)-DOF which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2,5-dimethoxy-4-fluorophenyl)-2-nitropropene → (+/-)-DOF (125903-69-7,697731-15-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 1.5h; Ambient temperature;

DOI:10.1021/jm00352a013

Reference yield:

2-fluoro-1,4-benzoquinone (367-28-2) → (+/-)-DOF (125903-69-7,697731-15-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 44 percent / NaOH / ethanol; H₂O / 0.5 h / 65 - 70 °C

2: 1.) SnCl₄, 2.) conc. HCl / 1.) CH₂Cl₂, RT, 30 min., 2.) H₂O, CH₂Cl₂, 1.5 h

3: 88.5 percent / NH₄OAc / 4 h / Heating

4: LiAlH₄ / tetrahydrofuran; diethyl ether / 1.5 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; ammonium acetate; tin(IV) chloride; In tetrahydrofuran; diethyl ether; ethanol; water;

DOI:10.1021/jm00352a013

Reference yield:

2-fluoro-1,4-dimethoxybenzene (82830-49-7) → (+/-)-DOF (125903-69-7,697731-15-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) SnCl₄, 2.) conc. HCl / 1.) CH₂Cl₂, RT, 30 min., 2.) H₂O, CH₂Cl₂, 1.5 h

2: 88.5 percent / NH₄OAc / 4 h / Heating

3: LiAlH₄ / tetrahydrofuran; diethyl ether / 1.5 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; ammonium acetate; tin(IV) chloride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jm00352a013

upstream raw materials:

2-fluoro-1,4-benzoquinone

2-fluoro-1,4-dimethoxybenzene

2,5-dimethoxy-4-fluorobenzaldehyde

Refernces