dimethyl 2,4-dibromopentanedioate

Base Information

• Chemical Name: dimethyl 2,4-dibromopentanedioate
• CAS No.: 31448-67-6
• Molecular Formula: C₇H₁₀Br₂O₄
• Molecular Weight: 317.962
• Mol file: 31448-67-6.mol

Synonyms:

Chemical Property of dimethyl 2,4-dibromopentanedioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 2,4-dibromopentanedioate

There total 12 articles about dimethyl 2,4-dibromopentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + gloutaric dichloride (2873-74-7) → dimethyl 2,4-dibromopentanedioate (31358-13-1,31448-67-6,149198-10-7,869-09-0)

Guidance literature:

gloutaric dichloride; With bromine; at 90 ℃; for 4h; UV-irradiation;

methanol; at 20 ℃; for 12h;

Reference yield:

methanol (67-56-1) + α,α'-dibromoglutaric acid (3479-80-9) → dimethyl α,α'-dibromoglutarate (31448-67-6) + Dimethyl (+/-)-2,4-dibromoglutarate (869-09-0,31358-13-1,31448-67-6,149198-10-7)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃; for 48h; Overall yield = 87 %; Overall yield = 9.77 g;

DOI:10.1016/j.poly.2013.05.012

Reference yield:

methanol (67-56-1) + α,α'-dibromoglutaric acid (3479-80-9) → dimethyl α,α'-dibromoglutarate (31448-67-6) + Dimethyl (+/-)-2,4-dibromoglutarate (869-09-0,31358-13-1,31448-67-6,149198-10-7)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃; for 48h; Overall yield = 87 %; Overall yield = 9.77 g;

DOI:10.1016/j.poly.2013.05.012

upstream raw materials:

methanol

1,5-pentanedioic acid

gloutaric dichloride

diazomethane

Downstream raw materials:

3-benzyl-3,6-diazabicyclo[3.1.1]heptane

6-propionyl-3,6-diazabicyclo[3.1.1]heptane

3,6-diazabicyclo[3.1.1]heptane-6-carboxylic acid tert-butyl ester

dimethyl 2,7-diisothiocyanatosuberate

Refernces

• 1、 Sattler, Wesley,Palmer, Joshua H.,Bridges, Christy C.,Joshee, Lucy,Zalups, Rudolfs K.,Parkin, Gerard. "Structural characterization of 1,3-propanedithiols that feature carboxylic acids: Homologues of mercury chelating agents". . p. 268 - 279. Retrieved 2013/10/08.
• 2、 -. "3,6-DIAZABICYCLOS[3.1.1]HEPTANE DERIVATIVES WITH ANALGESIC ACTIVITY". Page/Page column 10-13. . Retrieved 2010/02/14.