Technology Process of N1-(3-phenylbutanoyl)-N2-[3-(pyridin-2-yl)propyl]guanidine
There total 4 articles about N1-(3-phenylbutanoyl)-N2-[3-(pyridin-2-yl)propyl]guanidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride; 1,1'-carbonyldiimidazole;
In
N,N-dimethyl-formamide; mineral oil;
at 20 - 35 ℃;
for 6.75h;
Inert atmosphere;
DOI:10.1039/c3md00245d
- Guidance literature:
-
Multi-step reaction with 5 steps
1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C
2: hydrazine hydrate / ethanol / 20 °C
3: triethylamine / dichloromethane / 20 °C
4: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 20 °C
5: sodium hydride; 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide; mineral oil / 6.75 h / 20 - 35 °C / Inert atmosphere
With
di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; sodium hydride; hydrazine hydrate; triethylamine; triphenylphosphine; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c3md00245d
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrazine hydrate / ethanol / 20 °C
2: triethylamine / dichloromethane / 20 °C
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 20 °C
4: sodium hydride; 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide; mineral oil / 6.75 h / 20 - 35 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; sodium hydride; hydrazine hydrate; triethylamine; 1,1'-carbonyldiimidazole;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c3md00245d
