dydrogesterone

Base Information

• Chemical Name: dydrogesterone
• CAS No.: 601-33-2
• Molecular Formula: C₂₁H₂₈O₂
• Molecular Weight: 312.452
• Mol file: 601-33-2.mol

Synonyms:

Chemical Property of dydrogesterone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dydrogesterone

There total 29 articles about dydrogesterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.3%

7-Dehydro-9β,10α-progesteron (16484-70-1) → dydrogesterone (601-33-2,1162-56-7,2640-38-2,3795-24-2,25093-47-4,152-62-5)

Guidance literature:

With hydrogen bromide; acetic acid; at 0 ℃; Reagent/catalyst;

Reference yield:

(9β,10α)-pregn-4-ene-3,20-dione (2755-10-4) → dydrogesterone (601-33-2,1162-56-7,2640-38-2,3795-24-2,25093-47-4,152-62-5)

Guidance literature:

With chloranil; In tert-butyl alcohol; at 20 - 85 ℃; Reagent/catalyst; Temperature; Inert atmosphere;

Reference yield:

Progesterone (57-83-0) → dydrogesterone (601-33-2,1162-56-7,2640-38-2,3795-24-2,25093-47-4,152-62-5)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 20 - 120 °C

2.1: rhodium(III) chloride hydrate; sodium periodate / tetrachloromethane; acetonitrile; water

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 20 - 80 °C

4.1: sodium tetrahydroborate; methanol / -55 °C

5.1: Rh/Al₂O₃; hydrogenchloride; hydrogen / water; ethanol / 20 °C

6.1: sodium hydroxide / tert-butyl alcohol / 0.5 h / 20 - 55 °C / Inert atmosphere

6.2: 1 h / 50 - 55 °C

7.1: chromium(VI) oxide; sulfuric acid / water; acetone / -10 - -5 °C

8.1: chloranil / tert-butyl alcohol / 20 - 85 °C / Inert atmosphere

With chromium(VI) oxide; hydrogenchloride; methanol; sodium tetrahydroborate; sodium periodate; rhodium(III) chloride hydrate; sulfuric acid; Rh/Al₂O₃; hydrogen; chloranil; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; In tetrachloromethane; ethanol; water; acetone; toluene; acetonitrile; tert-butyl alcohol;

upstream raw materials:

7-Dehydro-9β,10α-progesteron

Des-A-17α-Δ⁹-pregnen-5,20-dion

(9β,10α)-pregn-4-ene-3,20-dione

Progesterone

Downstream raw materials:

9β,10α-Pregna-4,6,8(14)-trien-3,20-dion

Refernces

• 1、 -. "Method for synthesizing dydrogesterone". Paragraph 0029-0031. . Retrieved 2021/05/19.
• 2、 -. "PROCESS FOR PREPARATION OF DYDROGESTERONE". . . Retrieved 2018/09/08.