C₂₇H₃₁ClN₂O₅

Base Information

• Chemical Name: C₂₇H₃₁ClN₂O₅
• CAS No.: 1345249-31-1
• Molecular Formula: C₂₇H₃₁ClN₂O₅
• Molecular Weight: 499.007
• Mol file: 1345249-31-1.mol

Synonyms:

Chemical Property of C₂₇H₃₁ClN₂O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₃₁ClN₂O₅

There total 6 articles about C₂₇H₃₁ClN₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-4-(3-amino-4-chlorophenyl)pyrrolidin-2-one (1252761-21-9) → C27H31ClN2O5 (1345249-31-1)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride; potassium iodide; sodium nitrite / water / 0 °C

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane; dichloromethane

3: dihydrogen peroxide / dichloromethane

4: caesium carbonate / 70 °C

With hydrogenchloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; dihydrogen peroxide; potassium acetate; caesium carbonate; potassium iodide; sodium nitrite; In 1,4-dioxane; dichloromethane; water; 1: Sandmeyer reaction;

DOI:10.1016/j.bmcl.2011.08.006

Reference yield:

tert-butyl (4R)-4-[4-chloro-3-(4,4,5,5-tetramethyl(1,3,2-dioxaborolan-2-yl))phenyl]-2-oxopyrrolidinecarboxylate (1252761-96-8) → C27H31ClN2O5 (1345249-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dihydrogen peroxide / dichloromethane

2: caesium carbonate / 70 °C

With dihydrogen peroxide; caesium carbonate; In dichloromethane;

DOI:10.1016/j.bmcl.2011.08.006

Reference yield:

(R)-4-(4-chloro-3-nitrophenyl)pyrrolidin-2-one (1252761-51-5) → C27H31ClN2O5 (1345249-31-1)

Guidance literature:

Multi-step reaction with 5 steps

1: iron; acetic acid / 50 °C

2: hydrogenchloride; potassium iodide; sodium nitrite / water / 0 °C

3: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane; dichloromethane

4: dihydrogen peroxide / dichloromethane

5: caesium carbonate / 70 °C

With hydrogenchloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; dihydrogen peroxide; potassium acetate; iron; caesium carbonate; acetic acid; potassium iodide; sodium nitrite; In 1,4-dioxane; dichloromethane; water; 2: Sandmeyer reaction;

DOI:10.1016/j.bmcl.2011.08.006

upstream raw materials:

4-(bromomethyl)quinoline

ethanol

tert-butyl (R)-4-(4-chloro-3-hydroxyphenyl)-2-oxopyrrolidine-1-carboxylate

(R)-4-(3-amino-4-chlorophenyl)pyrrolidin-2-one

Downstream raw materials:

C₂₀H₁₉ClN₂O₃

Refernces