C₁₉H₁₆ClNO

Base Information

• Chemical Name: C₁₉H₁₆ClNO
• CAS No.: 1330074-82-2
• Molecular Formula: C₁₉H₁₆ClNO
• Molecular Weight: 309.795
• Mol file: 1330074-82-2.mol

Synonyms:

Chemical Property of C₁₉H₁₆ClNO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₆ClNO

There total 4 articles about C₁₉H₁₆ClNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyanomethylbenzoic acid (6627-91-4) → C19H16ClNO (1330074-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus pentachloride / dichloromethane / 0 - 20 °C

2: potassium carbonate / acetone / 10 h / Reflux

With phosphorus pentachloride; potassium carbonate; In dichloromethane; acetone;

DOI:10.1039/c1ob05082f

Reference yield:

benzaldehyde (100-52-7) → C19H16ClNO (1330074-82-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triphenylphosphine / 5,5-dimethyl-1,3-cyclohexadiene / 12 h / Reflux

1.2: 12 h / Reflux

2.1: phosphorus tribromide / benzene / 3.17 h / Cooling with ice; Reflux

3.1: potassium carbonate / acetone / 10 h / Reflux

With phosphorus tribromide; potassium carbonate; triphenylphosphine; In 5,5-dimethyl-1,3-cyclohexadiene; acetone; benzene; 1.1: Wittig reaction / 1.2: Wittig reaction;

DOI:10.1039/c1ob05082f

Reference yield:

4-phenylbuta-3-en-1-ol (770-36-5,20047-19-2,937-58-6) → C19H16ClNO (1330074-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus tribromide / benzene / 3.17 h / Cooling with ice; Reflux

2: potassium carbonate / acetone / 10 h / Reflux

With phosphorus tribromide; potassium carbonate; In acetone; benzene;

DOI:10.1039/c1ob05082f

upstream raw materials:

3-chloroisoquinolin-1(2H)-one

(4-bromo-1-buten-1-yl)benzene

4-phenylbuta-3-en-1-ol

benzaldehyde

Refernces