4',5,7-tri-O-trimethylsilyloxyisoflavone

Base Information

• Chemical Name: 4',5,7-tri-O-trimethylsilyloxyisoflavone
• CAS No.: 148356-36-9
• Molecular Formula: C₂₄H₃₄O₅Si₃
• Molecular Weight: 486.787
• Mol file: 148356-36-9.mol

Synonyms:

Chemical Property of 4',5,7-tri-O-trimethylsilyloxyisoflavone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4',5,7-tri-O-trimethylsilyloxyisoflavone

There total 8 articles about 4',5,7-tri-O-trimethylsilyloxyisoflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid 3,5-bis-benzyloxy-2-[(E)-3-(4-benzyloxy-phenyl)-acryloyl]-phenyl ester → 4',5,7-tri-O-trimethylsilyloxyisoflavone (148356-36-9)

Guidance literature:

Multi-step reaction with 4 steps

1: thallium nitrate / CHCl₃ / Ambient temperature

2: 37.2 percent / H₂, triethylamine / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

3: 5percent HCl / methanol / 2 h / Heating

4: hexamethyldisilazane, pyridine / 0.5 h / Ambient temperature

With pyridine; hydrogenchloride; thallium(I) nitrate; hydrogen; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; palladium on activated charcoal; In methanol; chloroform; ethyl acetate;

Reference yield:

Acetic acid 3,5-bis-benzyloxy-2-[2-(4-benzyloxy-phenyl)-3,3-dimethoxy-propionyl]-phenyl ester → 4',5,7-tri-O-trimethylsilyloxyisoflavone (148356-36-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 37.2 percent / H₂, triethylamine / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

2: 5percent HCl / methanol / 2 h / Heating

3: hexamethyldisilazane, pyridine / 0.5 h / Ambient temperature

With pyridine; hydrogenchloride; hydrogen; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; palladium on activated charcoal; In methanol; ethyl acetate;

Reference yield:

chloro-trimethyl-silane (75-77-4) + 5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on (446-72-0) → 4',5,7-tri-O-trimethylsilyloxyisoflavone (148356-36-9)

Guidance literature:

With pyridine; 1,1,1,3,3,3-hexamethyl-disilazane; for 0.5h; Yield given; Ambient temperature;

upstream raw materials:

chloro-trimethyl-silane

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

N,O-Bis(trimethylsilyl)trifluoroacetamide

1-(2-acetoxy-4,6-dihydroxyphenyl)-3,3-dimethoxy-2-(4-hydroxyphenyl)propan-1-one

Downstream raw materials:

genistein 7-O-(tri-O-benzoyl-6-deoxy-α-L-talopyranoside)

genistein 4',7-di-O-(tri-O-benzoyl-6-deoxy-α-L-talopyranoside)

genistein 4'-O-(tri-O-acetyl-α-L-rhamnopyranoside)

genistein 4',7-di-O-(tri-O-acetyl-α-L-rhamnopyranoside)

Refernces

• 1、 Tekel, Jozef,Daeseleire, Els,Heeremans, An,Van Peteghem, Carlos. "Development of a simple method for the determination of genistein, daidzein, biochanin A, and formononetin (Biochanin B) in human urine". . p. 3489 - 3494. Retrieved 2007/10/03.