N-(3-(Diethylamino)phenyl)propionamide

Base Information

• Chemical Name: N-(3-(Diethylamino)phenyl)propionamide
• CAS No.: 22185-75-7
• Molecular Formula: C13H20N2O
• Molecular Weight: 220.315
• Hs Code.: 2924299090
• European Community (EC) Number: 244-827-7
• DSSTox Substance ID: DTXSID8066767
• Nikkaji Number: J285.457K
• Wikidata: Q72469165
• Mol file: 22185-75-7.mol

Synonyms:22185-75-7;N-(3-(Diethylamino)phenyl)propionamide;3-(N,N-Diethyl)amino propionanilide;N-[3-(DIETHYLAMINO)PHENYL]PROPIONAMIDE;n-[3-(diethylamino)phenyl]propanamide;Propanamide, N-[3-(diethylamino)phenyl]-;EINECS 244-827-7;Diethylamino-3-(propionylamino)benzene;Propanamide, N-(3-(diethylamino)phenyl)-;SCHEMBL9408526;3'-(Diethylamino)propionanilide;DTXSID8066767;FT-0613826;W-107495;2,3,6-Pyridinetricarboxylic acid, 4-phenyl-, 2,3,6-triethyl ester

Chemical Property of N-(3-(Diethylamino)phenyl)propionamide

Chemical Property:

• Vapor Pressure: 1.6E-06mmHg at 25°C
• Melting Point: 77-79 °C(Solv: ethanol (64-17-5))
• Refractive Index: 1.568
• Boiling Point: 397.318 °C at 760 mmHg
• PKA: 14.82±0.70(Predicted)
• Flash Point: 194.091 °C
• PSA: 32.34000
• Density: 1.049 g/cm³
• LogP: 2.95430
• Storage Temp.: 2-8°C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 220.157563266
• Heavy Atom Count: 16
• Complexity: 214

Purity/Quality:

99% ^*data from raw suppliers

N-(3-(Diethylamino)phenyl)propionamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)NC1=CC(=CC=C1)N(CC)CC

Technology Process of N-(3-(Diethylamino)phenyl)propionamide

There total 8 articles about N-(3-(Diethylamino)phenyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N,N-diethyl-1,3-benzenediamine (26513-20-2) + propionic acid anhydride (123-62-6) → N,N-diethyl-N'-propionyl-1,3-benzenediamine (22185-75-7)

Guidance literature:

In benzene; for 1h; Heating;

Reference yield:

diethyl sulfate (64-67-5) + 1-amino-3-propionylamino-benzene (22987-10-6) → N,N-diethyl-N'-propionyl-1,3-benzenediamine (22185-75-7)

Guidance literature:

With sodium carbonate; In water; at 25 ℃; for 10h; Yield given;

Reference yield:

N,N-diethyl-3-nitroaniline (2216-16-2) → N,N-diethyl-N'-propionyl-1,3-benzenediamine (22185-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / formic acid, triethylamine / 5percent Pd/C / 2.5 h / Heating

2: 77 percent / benzene / 1 h / Heating

With formic acid; triethylamine; palladium on activated charcoal; In benzene;

upstream raw materials:

diethyl sulfate

1-amino-3-propionylamino-benzene

N,N-diethyl-1,3-benzenediamine

propionic acid anhydride

Downstream raw materials:

N-[2-(2-Cyano-4,6-dinitro-phenylazo)-5-diethylamino-phenyl]-propionamide

N-[2-(2,6-Dicyano-4-nitro-phenylazo)-5-diethylamino-phenyl]-propionamide

N-[2-(2-Bromo-4,6-dinitro-phenylazo)-5-diethylamino-phenyl]-propionamide

(E)-N-(2-((2-bromo-6-cyano-4-nitrophenyl)diazenyl)-5-(diethylamino)phenyl)propionamide

Refernces

• 1、 Thiel, W.,Mayer, R.,Jauer, E.-A.,Modrow, H.,Dost, H.. "Synthesis and Spectral Characterization of Blue Dyes of the Benzene Series". . p. 497 - 514. Retrieved 2007/10/02.