Fluorescein (Solvent Yellow 94) 518-45-6

Base Information

• Chemical Name: Fluorescein (Solvent Yellow 94) 518-45-6
• CAS No.: 126605-73-0
• Molecular Formula: C₂₀H₁₂O₅
• Molecular Weight: 332.312
• Mol file: 126605-73-0.mol

Synonyms:

Chemical Property of Fluorescein (Solvent Yellow 94) 518-45-6

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Fluorescein (Solvent Yellow 94) 518-45-6

There total 76 articles about Fluorescein (Solvent Yellow 94) 518-45-6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

phthalic anhydride (85-44-9) + recorcinol (108-46-3) → fluorescein (2321-07-5,126605-73-0)

Guidance literature:

In phosphoric acid; for 0.00833333h; Microwave irradiation;

DOI:10.1135/cccc20021779

Reference yield: 80.0%

fluorescein diacetate (596-09-8) → fluorescein (2321-07-5,126605-73-0)

Guidance literature:

fluorescein diacetate; With sodium hydroxide; In methanol; water; for 1.5h; Heating / reflux;

With hydrogenchloride; In ethanol; water; at 20 - 25 ℃; for 1h; pH=1 - 2.5;

Reference yield: 78.3%

fluoresceinamine (3326-34-9) → fluorescein (2321-07-5,126605-73-0)

Guidance literature:

With oxygen; nitrogen(II) oxide; at 25 ℃; pH=7.4; Air; aq. HEPES buffer;

DOI:10.1021/ic300379u

upstream raw materials:

phthalic anhydride

2',4'-dihydroxy-4-acetophenone

3,4-pyridinecarboxylic acid

recorcinol

Downstream raw materials:

2-(6'-ethoxy-3'-oxo-3'H-xanthene-9'-yl)benzoic acid ethyl ester

methyl 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoate

3,7-Dihydroxy-11-<2'-carboxy-phenyl>-dibenzoxazepin

4'-Brom-fluorescein

Refernces

• 1、 Mchedlov-Petrossyan, Nikolay O.,Mayorga, Rafael Salinas. "Extraordinary Character of the Solvent Influence on Protolytic Equilibria: Inversion of the Fluorescein Ionization Constants in H2O-DMSO Mixtures". . p. 3025 - 3032. Retrieved 1992.
• 2、 Murale, Dhiraj P.,Kim, Hwajin,Choi, Wan Sung,Churchill, David G.. "Rapid and selective detection of Cys in living neuronal cells utilizing a novel fluorescein with chloropropionate-ester functionalities". . p. 5289 - 5292. Retrieved 2014.
• 3、 Torrey,Brewster. "-". . p. 862. Retrieved 1908.
• 4、 Imamura,Koizumi. "-". . p. 913,914. Retrieved 1956.
• 5、 Pan, Yan,Tiong, Kai Hung,Mak, Joon Wah,Abd-Rashid, Badrul Amini,Ismail, Zakiah,Ismail, Rusli,Ong, Chin Eng. "Inhibitory effects of cytochrome P450 enzymes CYP2C8, CYP2C9, CYP2C19 and CYP3A4 by Labisia pumila extracts". . p. 586 - 591,6. Retrieved 2012.
• 6、 Eshghi, Hossein,Mirzaie, Narges. "Ferric hydrogensulphate as a recyclable catalyst for the synthesis of fluorescein derivatives". . p. 504 - 509. Retrieved 2011.
• 7、 Goswami, Shyamaprosad,Aich, Krishnendu,Das, Sangita,Basu Roy, Sohini,Pakhira, Bholanath,Sarkar, Sabyasachi. "A reaction based colorimetric as well as fluorescence 'turn on' probe for the rapid detection of hydrazine". . p. 14210 - 14214. Retrieved 2014.
• 8、 Choi, Myung Gil,Cha, Sunyoung,Park, Ji Eun,Lee, Haekyung,Jeon, Hye Lim,Chang, Suk-Kyu. "Selective perborate signaling by deprotection of fluorescein and resorufin acetates". . p. 1468 - 1471. Retrieved 2010.
• 9、 Xu, Kehua,Liu, Xia,Tang, Bo,Yang, Guiwen,Yang, Yong,An, Liguo. "Design of a phosphinate-based fluorescent probe for superoxide detection in mouse peritoneal macrophages". . p. 1411 - 1416. Retrieved 2007.
• 10、 Nakahara, Ryosuke,Fujimoto, Tsuyoshi,Doi, Mitsunobu,Morita, Kanako,Yamaguchi, Takako,Fujita, Yoshikazu. "Fluorophotometric determination of hydrogen peroxide and other reactive oxygen species with fluorescein hydrazide (FH) and its crystal structure". . p. 977 - 981. Retrieved 2008.