N,N'-bis(3,5-diacetylphenyl) (isophthalic acid diamide)

Base Information

• Chemical Name: N,N'-bis(3,5-diacetylphenyl) (isophthalic acid diamide)
• CAS No.: 169765-30-4
• Molecular Formula: C₂₈H₂₄N₂O₆
• Molecular Weight: 484.508
• Mol file: 169765-30-4.mol

Synonyms:

Chemical Property of N,N'-bis(3,5-diacetylphenyl) (isophthalic acid diamide)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-bis(3,5-diacetylphenyl) (isophthalic acid diamide)

There total 4 articles about N,N'-bis(3,5-diacetylphenyl) (isophthalic acid diamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-diacetyl aniline (87533-49-1) + benzene-1,3-dicarbonyl dichloride (99-63-8) → N,N'-bis(3,5-diacetylphenyl) (isophthalic acid diamide) (169765-30-4)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1002/ardp.201500323

Reference yield:

5-nitrobenzene-1,3-dicarboxylic acid (618-88-2) → N,N'-bis(3,5-diacetylphenyl) (isophthalic acid diamide) (169765-30-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / 1.5 h / Inert atmosphere; Reflux

2.1: sodium hydride / tetrahydrofuran / 4 h / Inert atmosphere; Reflux

2.2: 16 h / Inert atmosphere; Reflux

3.1: acetic acid; sulfuric acid / water / 3.5 h / Reflux

4.1: hydrogenchloride; tin(ll) chloride / water / 0.25 h / 50 °C

5.1: pyridine / dichloromethane / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; thionyl chloride; sulfuric acid; sodium hydride; acetic acid; N,N-dimethyl-formamide; tin(ll) chloride; In tetrahydrofuran; dichloromethane; water;

DOI:10.1002/ardp.201500323

Reference yield:

tetraethyl 5-nitroisophthaloylbis(malonate) (87555-27-9) → N,N'-bis(3,5-diacetylphenyl) (isophthalic acid diamide) (169765-30-4)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; sulfuric acid / water / 3.5 h / Reflux

2: hydrogenchloride; tin(ll) chloride / water / 0.25 h / 50 °C

3: pyridine / dichloromethane / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; sulfuric acid; acetic acid; tin(ll) chloride; In dichloromethane; water;

DOI:10.1002/ardp.201500323

upstream raw materials:

3,5-diacetyl aniline

benzene-1,3-dicarbonyl dichloride

5-nitrobenzene-1,3-dicarboxylic acid

tetraethyl 5-nitroisophthaloylbis(malonate)

Refernces