99-63-8 Usage
Description
1,3-Benzenedicarbonyl chloride, also known as isophthaloyl dichloride, is an organic compound with the chemical formula C8H4Cl2O2. It is a white crystalline solid that is soluble in organic solvents and has a pungent odor. 1,3-Benzenedicarbonyl chloride is commonly used as a chemical intermediate in the synthesis of various polymers, dyes, synthetic fibers, resins, films, protective coatings, and laboratory reagents.
Uses
Used in Performance Polymers and Fibers:
1,3-Benzenedicarbonyl chloride is used as a monomer in the production of performance polymers and fibers, where it contributes to flame resistance, temperature stability, chemical resistance, and flexibility. Its presence in these materials enhances their overall performance and durability.
Used in Urethane Prepolymers:
1,3-Benzenedicarbonyl chloride is used as an effective stabilizer for urethane prepolymers due to its ability to scavenge water. This property helps prevent the degradation of the prepolymer and ensures its stability during processing and application.
Used in Aromatic Fiber Raw Materials:
1,3-Benzenedicarbonyl chloride is used in the production of aromatic fiber raw materials, where it plays a crucial role in the synthesis of the fibers. Its presence in the raw materials contributes to the development of high-performance fibers with desirable properties.
Used as a Crosslinking Agent:
1,3-Benzenedicarbonyl chloride acts as a crosslinking agent in various polymerization reactions. It helps in forming covalent bonds between polymer chains, resulting in the formation of a three-dimensional network structure. This crosslinking enhances the mechanical properties, thermal stability, and chemical resistance of the resulting polymers.
Used in Dyes, Synthetic Fibers, Resins, Films, Protective Coatings, and Laboratory Reagents:
1,3-Benzenedicarbonyl chloride is used as a chemical intermediate in the synthesis of various dyes, synthetic fibers, resins, films, protective coatings, and laboratory reagents. Its versatile reactivity and functional groups make it a valuable component in the production of these materials, contributing to their unique properties and applications.
Flammability and Explosibility
Nonflammable
Check Digit Verification of cas no
The CAS Registry Mumber 99-63-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 9 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 99-63:
(4*9)+(3*9)+(2*6)+(1*3)=78
78 % 10 = 8
So 99-63-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H4Cl2O2/c9-7(11)5-2-1-3-6(4-5)8(10)12/h1-4H
99-63-8Relevant articles and documents
G4 Sensing Pyridyl-Thiazole Polyamide Represses c-KIT Expression in Leukemia Cells
Paul, Raj,Dutta, Debasish,Das, Tania,Debnath, Manish,Dash, Jyotirmayee
, p. 8590 - 8599 (2021)
Specific sensing and functional tuning of nucleic acid secondary structures remain less explored to date. Herein, we report a thiazole polyamide TPW that binds specifically to c-KIT1 G-quadruplex (G4) with sub-micromolar affinity and ~1 : 1 stoichiometry and represses c-KIT proto-oncogene expression. TPW shows up to 10-fold increase in fluorescence upon binding with c-KIT1 G4, but shows weak or no quantifiable binding to other G4s and ds26 DNA. TPW can increase the number of G4-specific antibody (BG4) foci and mark G4 structures in cancer cells. Cell-based assays reveal that TPW can efficiently repress c-KIT expression in leukemia cells via a G4-dependent process. Thus, the polyamide can serve as a promising probe for G-quadruplex recognition with the ability to specifically alter c-KIT oncogene expression.
Br?nsted acid-catalyzed chlorination of aromatic carboxylic acids
Yu, Zhiqun,Yao, Hongmiao,Xu, Qilin,Liu, Jiming,Le, Xingmao,Ren, Minna
supporting information, p. 685 - 689 (2021/04/09)
The chlorination of aromatic carboxylic acids with SOCl2 has been effectively performed by reacting with a Br?nsted acid as the catalyst. Based on this discovery, an efficient catalytic method that is cheaper than traditional catalytic methods was developed. 20 substrates were chlorinated offering excellent yields in a short reaction time. And the SOCl2/Br?nsted acid system has been used in a larger scale preparative reaction. A dual activation mechanism was proposed to prove the irreplaceable system of SOCl2/Br?nsted acid.
Synthesis, antimicrobial activity, and ion transportation investigation of four new [1 + 1] condensed furan and thiophene-based cycloheterophane amides
?zcan, Hafize,Erku?, Betül,Zaim, ?mer
, (2020/02/18)
Four new macrocyclic compounds with thiophene (L1 and L2) and furan (L3 and L4) rings were synthesized and characterized by IR, 1H NMR, 13C NMR, and Q-TOF spectral data. Macrocyclic amides (L1, L2, L3, and L4) were tested for ion transportation with Na+ and K+ ions, and also, antimicrobial activities were investigated against the Gram-negative Escherichia coli ATCC 25922, Gram-positive Staphylococcus aureus ATCC 25923, Gram-negative Listeria monocytogenes ATCC 19115, Gram-negative Salmonella typhimurium ATCC 14028, Bacillus cereus bacteria, and Candida albicans ATCC 10231 for all amides.