7477-29-4

Basic information

• Product Name: benzene-1,3-diylbis[(4-methoxyphenyl)methanone]
• Synonyms: 1,3-Phenylenebis[(4-methoxyphenyl)methanone]; methanone, 1,1'-(1,3-phenylene)bis[1-(4-methoxyphenyl)-
• CAS NO: 7477-29-4
• Molecular Formula: C₂₂H₁₈O₄
• Molecular Weight: 346.3759
• Mol File: 7477-29-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 531.6°C at 760 mmHg
• Flash Point: 233.5°C
• Density: 1.179g/cm³
• Vapor Pressure: 2.2E-11mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: benzene-1,3-diylbis[(4-methoxyphenyl)methanone](CAS DataBase Reference)
• NIST Chemistry Reference: benzene-1,3-diylbis[(4-methoxyphenyl)methanone](7477-29-4)
• EPA Substance Registry System: benzene-1,3-diylbis[(4-methoxyphenyl)methanone](7477-29-4)

Safety Data

• Hazardous Substances Data: 7477-29-4(Hazardous Substances Data)

Upstream product

• 100-66-3 methoxybenzene 
• 201230-82-2 carbon monoxide 
• 626-00-6 1,3-Diiodobenzene 
• 5720-07-0 4-methoxyphenylboronic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 65844-89-5 1,3-bis-(trimethylstannyl)benzene 
• 99-63-8 benzene-1,3-dicarbonyl dichloride 
• 33397-21-6 tris(4-methoxyphenyl)bismuth 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 5436-05-5 1, 3-phenylenebis ((4-hydroxyphenyl)methanone) 
• 77-78-1 dimethyl sulfate 
• 744-45-6 diphenyl isophthalate 

Downstream Products

• 1458033-45-8 1,3-bis-(4-isopropoxybenzoyl)benzene dithiosemicarbazone 
• 1458033-52-7 1,3-bis-(4-isopropoxybenzoyl)benzene 
• 1458033-44-7 1,3-bis-(4-isopropoxybenzoyl)benzene thiosemicarbazone 
• 1458033-51-6 1-(4-hydroxybenzoyl)-3-(4-methoxybenzoyl)benzene 
• 1458033-43-6 1-(4-hydroxybenzoyl)-3-(4-methoxybenzoyl)benzene thiosemicarbazone 
• 1458033-42-5 1-(4-methoxybenzoyl)-3-(4-hydroxybenzoyl)benzene thiosemicarbazone 
• 1458033-41-4 1-(4-hydroxybenzoyl)-3-(4-methoxybenzoyl)benzene dithiosemicarbazone 
• 1458033-40-3 1,3-bis-(4-methoxybenzoyl)benzene dithiosemicarbazone 
• 861079-56-3 3-(4-hydroxy-3-nitro-benzoyl)-benzoic acid 
• 860604-07-5 1,3-bis-(4-methoxy-3-nitro-benzoyl)-benzene 
• 5436-05-5 1, 3-phenylenebis ((4-hydroxyphenyl)methanone) 
• 873387-85-0 1,3-bis-(3-amino-4-methoxy-benzoyl)-benzene 

Relevant articles and documents

Novel and efficient bridged bis(N-heterocyclic carbene)palladium(II) catalysts for selective carbonylative Suzuki–Miyaura coupling reactions to biaryl ketones and biaryl diketones

Bridged N,N′-substituted bisbenzimidazolium bromide salts (L1, L2, and L3) were synthesized and fully characterized. Reactions of palladium acetate with L1, L2, and L3 afforded corresponding new bridged bis(N-heterocyclic carbene)palladium(II) complexes (C1, C2, and C3) in high yields. The X-ray structure of complex C1 showed that the Pd(II) ion is bonded to the two carbon atoms of the bis(N-heterocyclic carbene) and two bromido ligands are in the cis position, resulting in a distorted square planar geometry. The three Pd(NHC)2Br2 complexes C1, C2, and C3 were evaluated in carbonylative Suzuki–Miyaura coupling reactions of aryl boronic acids with aryl halides and displayed high catalytic activity with low catalyst loading. The coupling reactions of aryl bromides were selective towards the carbonylation product at higher carbon monoxide pressure.

COMPOSITIONS AND METHODS FOR INHIBITION OF CATHEPSINS

This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.

Efficient catalyst-free bi- and triaroylation of aromatic rings in a single step

(Chemical Equation Presented) The exceptional leaving group ability of the trimethylstannyl group in electrophilic aromatic substitutions makes possible the synthesis, in a single step, of bi- and triaroylarenes through the catalyst-free, regioselective reaction of bi- and tristannylarenes with different aroyl halides in o-dichlorobenzene as solvent. Specific di- and triketones are obtained in good to excellent yields (45-83%).