2-<2-(6-Amidino-1-benzofuran-2-yl)-(E)-vinyl>-1-benzofuran-5-carboxamidin-dihydrochlorid

Base Information

• Chemical Name: 2-<2-(6-Amidino-1-benzofuran-2-yl)-(E)-vinyl>-1-benzofuran-5-carboxamidin-dihydrochlorid
• CAS No.: 84223-79-0
• Molecular Formula: C₂₀H₁₆N₄O₂*2ClH
• Molecular Weight: 417.295
• Mol file: 84223-79-0.mol

Synonyms:

Chemical Property of 2-<2-(6-Amidino-1-benzofuran-2-yl)-(E)-vinyl>-1-benzofuran-5-carboxamidin-dihydrochlorid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<2-(6-Amidino-1-benzofuran-2-yl)-(E)-vinyl>-1-benzofuran-5-carboxamidin-dihydrochlorid

There total 15 articles about 2-<2-(6-Amidino-1-benzofuran-2-yl)-(E)-vinyl>-1-benzofuran-5-carboxamidin-dihydrochlorid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-benzofurancarboxylic acid methyl ester (26028-36-4) → 2-<2-(6-Amidino-1-benzofuran-2-yl)-(E)-vinyl>-1-benzofuran-5-carboxamidin-dihydrochlorid (84223-79-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / N-methylpyrrolidine / 0.5 h / Heating

2: 95 percent / 1) NaHCO₃, CaI₂, NaBH₄; 2) CaI₂, NaBH₄ / tetrahydrofuran / 1) 0 to 5 deg C, 1 h; 2) room temp., 2 h

3: 95 percent / HNO₃ / 0.02 h / 60 °C

4: 78 percent / CH₃ONa / methanol / 1 h / Ambient temperature

5: 1) HCl (g); 2) NH₃ (g) / 1) nitrobenzol, ethanol, 7 d; 2) ether, ethanol, 7 d

With 1-Methylpyrrolidine; hydrogenchloride; sodium tetrahydroborate; ammonia; nitric acid; sodium methylate; sodium hydrogencarbonate; calcium iodide; In tetrahydrofuran; methanol;

Reference yield:

5-bromobenzo[b]furan-2-carboxylic acid (10242-11-2) → 2-<2-(6-Amidino-1-benzofuran-2-yl)-(E)-vinyl>-1-benzofuran-5-carboxamidin-dihydrochlorid (84223-79-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 95 percent / conc. H₂SO₄ / 15 h / Heating

2: 80 percent / N-methylpyrrolidine / 0.5 h / Heating

3: 95 percent / 1) NaHCO₃, CaI₂, NaBH₄; 2) CaI₂, NaBH₄ / tetrahydrofuran / 1) 0 to 5 deg C, 1 h; 2) room temp., 2 h

4: 95 percent / HNO₃ / 0.02 h / 60 °C

5: 78 percent / CH₃ONa / methanol / 1 h / Ambient temperature

6: 1) HCl (g); 2) NH₃ (g) / 1) nitrobenzol, ethanol, 7 d; 2) ether, ethanol, 7 d

With 1-Methylpyrrolidine; hydrogenchloride; sodium tetrahydroborate; sulfuric acid; ammonia; nitric acid; sodium methylate; sodium hydrogencarbonate; calcium iodide; In tetrahydrofuran; methanol;

Reference yield:

3-hydroxy-4-methylbenzonitrile (3816-66-8) → 2-<2-(6-Amidino-1-benzofuran-2-yl)-(E)-vinyl>-1-benzofuran-5-carboxamidin-dihydrochlorid (84223-79-0)

Guidance literature:

Multi-step reaction with 10 steps

1: 100 percent / pyridine / 3 h / Heating

2: 98 percent / N-bromsuccinimide, dibenzoylperoxide / CCl₄ / 8 h / Heating

3: 63 percent / 50 percent NaOH / methanol / 0.33 h / Heating

4: 1) KOH, NaOH; 2) H₂SO₄ / 1) 1 h, reflux, ethanol; water, room temp., 2) 1 h, reflux

5: 88 percent / conc. H₂SO₄ / 15 h / Heating

6: 78 percent / 1) NaHCO₃, CaI₂, NaBH₄; 2) CaI₂, NaBH₄ / tetrahydrofuran / 1) 0 to 5 deg C, 1 h; 2) room temp., 2 h

7: 84 percent / pyridine, SOCl₂ / diethyl ether / 4 h / Ambient temperature

8: 74 percent / xylene / 2 h / Heating

9: 78 percent / CH₃ONa / methanol / 1 h / Ambient temperature

10: 1) HCl (g); 2) NH₃ (g) / 1) nitrobenzol, ethanol, 7 d; 2) ether, ethanol, 7 d

With pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; thionyl chloride; sulfuric acid; ammonia; sodium methylate; sodium hydrogencarbonate; calcium iodide; dibenzoyl peroxide; In tetrahydrofuran; pyridine; methanol; tetrachloromethane; diethyl ether; xylene;

upstream raw materials:

2-<2-(6-Cyan-1-benzofuran-2-yl)-(E)-vinyl>-1-benzofuran-5-carbonitril

5-bromo-2-benzofurancarboxylic acid methyl ester

5-bromobenzo[b]furan-2-carboxylic acid

3-hydroxy-4-methylbenzonitrile

Refernces