26028-36-4 Usage
Description
5-BROMOBENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER is an organic compound that serves as a key intermediate in the synthesis of various chemical compounds. It is characterized by the presence of a bromo substituent on the benzofuran ring and a carboxylic acid group, which is esterified with a methyl group. This unique structure endows it with versatile reactivity and potential applications in different fields.
Uses
Used in Pharmaceutical Industry:
5-BROMOBENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER is used as a synthetic intermediate for the development of biscationic 1-benzofuran compounds. These biscationic compounds exhibit trypanocidal activity, making them valuable in the treatment of trypanosome infections, such as Chagas disease and African sleeping sickness.
In the synthesis process, 5-BROMOBENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER can be further modified and functionalized to create a variety of biscationic 1-benzofuran derivatives with improved pharmacological properties. These modifications can enhance the compound's potency, selectivity, and bioavailability, leading to more effective treatments for trypanosome infections.
Overall, 5-BROMOBENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER plays a crucial role in the pharmaceutical industry as a building block for the development of novel and effective trypanocidal agents. Its unique structure and reactivity make it a valuable asset in the ongoing search for new treatments to combat these devastating diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 26028-36-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,0,2 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 26028-36:
(7*2)+(6*6)+(5*0)+(4*2)+(3*8)+(2*3)+(1*6)=94
94 % 10 = 4
So 26028-36-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H7BrO3/c1-13-10(12)9-5-6-4-7(11)2-3-8(6)14-9/h2-5H,1H3
26028-36-4Relevant articles and documents
Direct Alkoxycarbonylation of Heteroarenes via Cu-Mediated Trichloromethylation and in Situ Alcoholysis
Jiang, Huanfeng,Jiang, Kai,Li, Yingwei,Luo, Wenkun,Yin, Biaolin
supporting information, (2020/03/04)
We report an efficient approach for direct alkoxycarbonylation of furans as well as other heteroarenes via a one-step copper-mediated reaction of three components (i.e., heteroarene, alcohol, and CHCl3). The copper additive was confirmed to simultaneously promote the reaction in three pathways: oxidant cracking, single electron transfer, and alcoholysis. By means of this protocol, various functionalized furancarboxylates and other heteroarenecarboxylates were facilely obtained in moderate to good yields.
PROTEIN KINASE C AGONISTS
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Paragraph 0323, (2020/09/12)
The present disclosure relates generally to certain diacylglycerol lactone compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions dis
HETEROCYCLIC COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS FOR THE TREATMENT OF HYPERPARATHYROIDISM, CHRONIC RENAL FAILURE AND CHRONIC KIDNEY DISEASE
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Page/Page column 48, (2015/11/16)
The invention relates to heterocyclic compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their pharmaceutical compositions for use in medicine for the treatment of diseases or disorders associated with the modulation of calcium sensing receptor modulators (CaSR), like e.g. hyperparathyroidism, chronic renal failure and chronic kidney disease and their complications.
