23145-16-6 Usage
Description
5-BROMO-1-BENZOFURAN-2-CARBALDEHYDE, also known as 5-Bromobenzo[b]furan-2-carbaldehyde, is a white to light yellow crystalline powder with distinct chemical properties. It is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical and chemical products.
Uses
Used in Pharmaceutical Industry:
5-BROMO-1-BENZOFURAN-2-CARBALDEHYDE is used as a key intermediate in the synthesis of biscationic, trypanocidal 1-benzofuran compounds. These compounds are of significant interest due to their potential applications in the development of new drugs for the treatment of trypanosomiasis, a group of parasitic diseases transmitted by the bite of infected tsetse flies.
In the synthesis of these biscationic, trypanocidal 1-benzofuran compounds, 5-BROMO-1-BENZOFURAN-2-CARBALDEHYDE plays a crucial role in providing the necessary structural framework and functional groups required for the biological activity of the final product. The development of these compounds can lead to more effective treatments for trypanosomiasis, which is a significant health concern in many parts of the world.
Additionally, due to its unique chemical properties and reactivity, 5-BROMO-1-BENZOFURAN-2-CARBALDEHYDE may also find applications in other areas of the pharmaceutical industry, such as the synthesis of other bioactive compounds or as a building block for the development of novel drug candidates.
Check Digit Verification of cas no
The CAS Registry Mumber 23145-16-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,1,4 and 5 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 23145-16:
(7*2)+(6*3)+(5*1)+(4*4)+(3*5)+(2*1)+(1*6)=76
76 % 10 = 6
So 23145-16-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H5BrO2/c10-7-1-2-9-6(3-7)4-8(5-11)12-9/h1-5H
23145-16-6Relevant articles and documents
A study of the Claisen-Eschenmoser reaction for hydroxymethylbenzofurans and-indoles
Mukhanova,Kukushkin,Ivanov,Alekseeva,Granik
, p. 325 - 329 (2007)
N,N-Dimethylacetamide dimethyl acetal reacted with 5(7)-substituted 2-(hydroxy-methyl)benzofurans to give N,N-dimethyl-2-(2-methylbenzofuran-3-yl) acetamides. Analogous reactions with 3-(hydroxymethyl)indole and 1-hydroxy-6-methyl-1,2,3,4-tetrahydro-carbazole afforded N,N-dimethyl-3-(3- indolyl)propionamide and N, N-dimethyl-2-(6-methyl-1,2,3,4-tetrahydrocarbazol-1- yl)acetamide, respectively.
PD-1/PD-L1 INHIBITORS
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Page/Page column 409; 410, (2018/11/22)
Compounds according to formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES
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, (2015/04/15)
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).
