Cbo-L-alanyl-aminomalonsaeurediethylester

Base Information

• Chemical Name: Cbo-L-alanyl-aminomalonsaeurediethylester
• CAS No.: 21024-83-9
• Molecular Formula: C₁₈H₂₄N₂O₇
• Molecular Weight: 380.398
• Mol file: 21024-83-9.mol

Synonyms:

Chemical Property of Cbo-L-alanyl-aminomalonsaeurediethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cbo-L-alanyl-aminomalonsaeurediethylester

There total 2 articles about Cbo-L-alanyl-aminomalonsaeurediethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aminomalonic acid diethyl ester (6829-40-9) + N-Cbz-Ala (1142-20-7) → Cbo-L-alanyl-aminomalonsaeurediethylester (21024-83-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1039/j39690001003

Reference yield:

aminomalonic acid diethyl ester (6829-40-9) + N-benzyloxycarbonyl-L-alanyl chloride (49760-60-3) → Cbo-L-alanyl-aminomalonsaeurediethylester (21024-83-9)

Guidance literature:

With ethyl acetate;

Reference yield: 87.0%

Cbo-L-alanyl-aminomalonsaeurediethylester (21024-83-9) → 3-Ethoxycarbonyl-6-methyl-piperazin-2,5-dion (63891-87-2,86783-98-4,86783-99-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 70 ℃; for 2h;

DOI:10.1002/ardp.19833160716

upstream raw materials:

aminomalonic acid diethyl ester

N-benzyloxycarbonyl-L-alanyl chloride

N-Cbz-Ala

Downstream raw materials:

[(N-benzyloxycarbonyl-L-alanyl)-amino]-malonic acid

3-Ethoxycarbonyl-6-methyl-piperazin-2,5-dion

Z-L-Ala-DL-Ama(OBzl)-OH