6829-40-9

Basic information

• Product Name: 2-AMINODIETHYLMALONATE
• Synonyms: AMINOMALONIC ACID DIETHYL ESTER;2-AMINODIETHYLMALONATE;DIETHYL AMINOMALONATE;Aminopropanedioicaciddiethylester;Ethylaminomalonate;DIETHYL AMINOMALINATE;2-Aminomalonic acid diethyl;2-Aminomalonic acid diethyl ester
• CAS NO: 6829-40-9
• Molecular Formula: C₇H₁₃NO₄
• Molecular Weight: 175.18
• EINECS: 229-905-0
• Product Categories: Pharmaceutical Intermediates;straight chain compounds;Amines;Intermediates
• Mol File: 6829-40-9.mol
• Article Data: 29

Chemical Properties

• Melting Point: 170 °C
• Boiling Point: 306.47°C (rough estimate)
• Flash Point: 52.3 °C
• Appearance: Colourless oil
• Density: 1.1000
• Refractive Index: 1.4353 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 15.34±0.59(Predicted)
• CAS DataBase Reference: 2-AMINODIETHYLMALONATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINODIETHYLMALONATE(6829-40-9)
• EPA Substance Registry System: 2-AMINODIETHYLMALONATE(6829-40-9)

Safety Data

• Hazardous Substances Data: 6829-40-9(Hazardous Substances Data)

Usage

Chemical Properties

2-AMINODIETHYLMALONATE is colourless Oil

Uses

Different sources of media describe the Uses of 6829-40-9 differently. You can refer to the following data:
1. Reagent used in the synthesis of Imidazole derivatives.
2. 2-AMINODIETHYLMALONATE is used in the synthesis of Imidazole derivatives.

InChI:InChI=1/C7H14NO4/c1-3-7(8,4-2,5(9)10)6(11)12/h3-4,8H2,1-2H3,(H,9,10)(H,11,12)/p-2

Upstream product

• 6829-41-0 diethyl oximinomalonate 
• 603-67-8 diethyl nitromalonate 
• 105-53-3 diethyl malonate 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 6326-44-9 diethyl 2-formylaminomalonate 
• 13433-00-6 diethyl aminomalonate hydrochloride 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 996-82-7 sodium diethylmalonate 
• 64-17-5 ethanol 
• 91469-69-1 ethylesters of amino malonic acid 
• 168207-98-5 diethyl 2,2-diazidomalonate 

Downstream Products

• 114282-94-9 (benzylsulfanylthiocarbonyl-amino)-malonic acid diethyl ester 
• 14769-29-0 diethyl 2-[[2-(benzyloxycarbonylamino)acetyl]amino]propanedioate 
• 500791-38-8 (2-phenyl-thioacetylamino)-malonic acid diethyl ester 
• 21024-83-9 Cbo-L-alanyl-aminomalonsaeurediethylester 
• 32683-00-4 ethyl 2-phenylimidazole-4-carboxylate 
• 62009-47-6 2-aminopropanediamide 
• 56-40-6 glycine 
• 617-45-8 aspartic Acid 
• 142-73-4 iminodiacetic acid 
• 609-36-9 rac-Pro-OH 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 96-86-6 diethyl benzamidomalonate 
• 54001-50-2 2-(3-phenylureido)malonic acid diethyl ester 
• 129221-15-4 2-(4-nitrobenzoylamino)propanedioic acid diethyl ester 

Relevant articles and documents

Regiochemistry in 1,3-dipolar cycloadditions of the azomethine ylide formed from diethyl aminomalonate and paraformaldehyde

The azomethine ylide derived from the condensation of diethyl aminomalonate with paraformaldehyde undergoes 1,3-dipolar cycloadditions with acrylate and propiolate derivatives. Contrary to a previous report, these reactions yield mixtures of regioisomers

AN IMPROVED HYDROGENATION PROCESS USING A TRANSITION METAL COMPLEX CATALYST

The present invention relates to the process of reduction of compound of formula (II) by using a transition metal complex (Z) as a catalyst for hydrogenation reactions to get compound of formula (I). More particularly, the present invention relates to an improved process for the preparation of a compound (I) (as described herein) or a salt thereof; comprising hydrogenation of the compound (II) (as described herein) using a transition metal complex catalyst (Z).

Preparation method of diethyl amino-malonate hydrochloride

The preparation method comprises first steps of preparing diethyl malonate in acetic acid, subnitration with an aqueous solution of nitrous acid to obtain the oxime-based malonic acid diethyl ester. 2nd: The oxime-based malonate is subjected to catalytic hydrogenation reaction with a nickel-containing ternary catalyst in an alcohol solvent to obtain diethyl amino-malonate. 3rd-Step: After the catalyst is filtered off, the catalyst is salified with hydrogen chloride ethanol and then dissolved in acetone to obtain diethyl amino-malonate hydrochloride. The method has the characteristics of mild and safe reaction conditions, simple and convenient operation, high yield, low cost, good quality and the like, and has wide application prospects. In addition, the hydrogenation technology for the method not only avoids waste residues and waste acid generated by reduction of zinc powder, but also avoids the disadvantages of expensive price and easy poisoning inactivation of the palladium-carbon catalyst.