21-Acetyloxy DeschloroMoMetasone Furoate

Base Information

• Chemical Name: 21-Acetyloxy DeschloroMoMetasone Furoate
• CAS No.: 83897-05-6
• Molecular Formula: C₂₉H₃₃ClO₈
• Molecular Weight: 545.029
• Mol file: 83897-05-6.mol

Synonyms:

Chemical Property of 21-Acetyloxy DeschloroMoMetasone Furoate

Chemical Property:

• Solubility.: Dichloromethane, Ethyl Acetate

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

21-Acetyloxy Deschloromometasone Furoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 21-Acetyloxy Deschloromometasone Furoate is used in the preparation of series of novel topical corticosteroids.

Technology Process of 21-Acetyloxy DeschloroMoMetasone Furoate

There total 7 articles about 21-Acetyloxy DeschloroMoMetasone Furoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C29H32O8 (109183-56-4) → 9α-chloro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-(2'-furoate) 21-acetate (83897-05-6)

Guidance literature:

With hydrogenchloride; In acetic acid; for 45h;

DOI:10.1021/jm00392a010

Reference yield: 54.0%

16α-methyl-17α,21-dihydroxy-1,4,9(11)-pregnatriene-3,20-dione 17-(2'-furoate) 21-acetate (83880-61-9) → 9α-chloro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-(2'-furoate) 21-acetate (83897-05-6)

Guidance literature:

With perchloric acid; 1,3-dichloro-5,5-dimethylhydantoin; In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1021/jm00392a010

Reference yield:

2-furoic anhydride (615-08-7) → 9α-chloro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-(2'-furoate) 21-acetate (83897-05-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / 4-(dimethylamino)pyridine (4-DMAP) / CH₂Cl₂ / 144 h / Ambient temperature

2: 92 percent / HCl / acetic acid / 45 h

With hydrogenchloride; dmap; In dichloromethane; acetic acid;

DOI:10.1021/jm00392a010

upstream raw materials:

16α-methyl-17α,21-dihydroxy-1,4,9(11)-pregnatriene-3,20-dione 17-(2'-furoate) 21-acetate

C₂₉H₃₂O₈

2-furoic anhydride

17α,21-dihydroxy-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate

Downstream raw materials:

C₂₇H₃₁ClO₇

Refernces

• 1、 Shapiro, Elliot L.,Gentles, Margaret J.,Tiberi, Robert L.,Popper, Thomas L.,Berkenkopf, Joseph,et al.. "17-Heteroaroyl Esters of Corticosteroids. 2. 11β-Hydroxy Series". . p. 1581 - 1588. Retrieved 2007/10/02.