C₂₁H₂₆ClNO₂

Base Information

• Chemical Name: C₂₁H₂₆ClNO₂
• CAS No.: 108825-05-4
• Molecular Formula: C₂₁H₂₆ClNO₂
• Molecular Weight: 359.896
• Mol file: 108825-05-4.mol

Synonyms:

Chemical Property of C₂₁H₂₆ClNO₂

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

ClemastineN-Oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Clemastine N-Oxide (Clemastine EP Impurity A) is a metabolite of Clemastine Fumarate (C568500); a H1 histamine receptor antagonist and antihistaminic.

Technology Process of C₂₁H₂₆ClNO₂

There total 3 articles about C₂₁H₂₆ClNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Clemastin-hydrogenfumarat (63537-12-2) → 2-(1-methyl-2-pyrrolidine)ethanol (67004-64-2) + 1-(4-chloro-phenyl)-1-phenyl-ethanol (59767-24-7) + 2-{2-[1-(4-Chloro-phenyl)-1-phenyl-ethoxy]-ethyl}-pyrrolidine + Clemastin-N-oxid (108825-05-4)

Guidance literature:

With 1H-imidazole; dihydrogen peroxide; manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin chloride; In methanol; dichloromethane; at 20 ℃; for 24h; Further byproducts given;

Reference yield:

Clemastin-hydrogenfumarat (63537-12-2) → 1-(4-chlorophenyl)-1-phenylethene (18218-20-7) + 1-(4-chloro-phenyl)-1-phenyl-ethanol (59767-24-7) + 2-{2-[1-(4-Chloro-phenyl)-1-phenyl-ethoxy]-ethyl}-pyrrolidine + Clemastin-N-oxid (108825-05-4)

Guidance literature:

With 1H-imidazole; dihydrogen peroxide; manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin chloride; In methanol; dichloromethane; at 20 ℃; for 24h; Further byproducts given;

Reference yield:

MMV637229 (7723-51-5,15686-51-8,61826-27-5,61826-28-6,61826-31-1,63813-90-1,63813-91-2) → C21H26ClNO2 (108825-05-4)

Guidance literature:

With disodium hydrogenphosphate; potassium dihydrogenphosphate; extract of yeast; sodium chloride; Sucrose; In methanol; N,N-dimethyl-formamide; at 27 ℃; Microbiological reaction; aq. phosphate buffer;

DOI:10.1002/rcm.4535

upstream raw materials:

Clemastin-hydrogenfumarat

MMV₆₃₇₂₂₉

Refernces

• 1、 Froehlich,Pietzyk,Smolinka,Goeber. "Biomimetic oxidation of clemastine fumarate". . p. 409 - 414. Retrieved 2007/10/03.