3-chloro-2,6-dimethoxypyridine

Base Information

• Chemical Name: 3-chloro-2,6-dimethoxypyridine
• CAS No.: 158609-09-7
• Molecular Formula: C₇H₈ClNO₂
• Molecular Weight: 173.599
• Mol file: 158609-09-7.mol

Synonyms:

Chemical Property of 3-chloro-2,6-dimethoxypyridine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-2,6-dimethoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-chloro-2,6-dimethoxypyridine

There total 2 articles about 3-chloro-2,6-dimethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2,6-dimethoxypyridine (6231-18-1,122797-02-8) → 3-chloro-2,6-dimethoxypyridine (158609-09-7)

Guidance literature:

With N-chloro-succinimide; dimethyl sulfoxide; In chloroform; at 25 ℃; for 2h; Reagent/catalyst; Schlenk technique;

Reference yield: 73.0%

3-bromo-2,6-dimethoxypyridine (13445-16-4) → 3-chloro-2,6-dimethoxypyridine (158609-09-7)

Guidance literature:

3-bromo-2,6-dimethoxypyridine; With n-butyllithium; isopropylmagnesium chloride; In tetrahydrofuran; hexane; at -2 - 0 ℃; for 0.75h; Inert atmosphere;

With hexachloroethane; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1055/s-0031-1289687

upstream raw materials:

3-bromo-2,6-dimethoxypyridine

2,6-dimethoxypyridine

Refernces

• 1、 Struk, Lukasz,Sosnicki, Jacek G.. "Noncryogenic synthesis of functionalized 2-methoxypyridines by halogen-magnesium exchange using lithium dibutyl(isopropyl)magnesate(1-) and lithium chloride". experimental part. p. 735 - 746. Retrieved 2012/04/04.