C₁₆H₁₆N₂O₅

Base Information

• Chemical Name: C₁₆H₁₆N₂O₅
• CAS No.: 475479-10-8
• Molecular Formula: C₁₆H₁₆N₂O₅
• Molecular Weight: 316.313
• Mol file: 475479-10-8.mol

Synonyms:

Chemical Property of C₁₆H₁₆N₂O₅

Chemical Property:

Purity/Quality:

(E)-Methyl3-methoxy-2-(2-((6-methoxypyrimidin-4-yl)oxy)phenyl)acrylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (E)-Methyl 3-methoxy-2-(2-((6-methoxypyrimidin-4-yl)oxy)phenyl)acrylate is an intermediate used in the preparation of β-methoxyacrylate analogs with antifungal activity.

Technology Process of C₁₆H₁₆N₂O₅

There total 10 articles about C₁₆H₁₆N₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-((α)‐2‐(2‐(6‐chloropyrimidin-4‐yl)oxy)phenyl)methyl-3-methoxyacrylate (383428-73-7) + sodium methylate (124-41-4) → C16H16N2O5 (475479-10-8)

Guidance literature:

In methanol; Reflux;

Reference yield: 69.0%

methanol (67-56-1) + (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate (131860-97-4) → C16H16N2O5 (475479-10-8)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1002/jccs.201200295

Reference yield:

2-(2-hydroxyphenyl)-3,3-dimethoxypropionic acid methyl ester (175971-61-6) → C16H16N2O5 (475479-10-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2: methanesulfonic acid / acetic anhydride / 2 h / 90 °C

3: potassium carbonate; 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; methanesulfonic acid; potassium carbonate; In acetic anhydride; N,N-dimethyl-formamide;

DOI:10.1002/jccs.201200295

upstream raw materials:

3-(α-methoxy)methylene benzofuran-2-(3H)-ketone

2-(2-hydroxyphenyl)-3,3-dimethoxypropionic acid methyl ester

2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3,3-dimethoxypropionic acid methyl ester

2-Hydroxyphenylacetic acid

Refernces

• 1、 Liu, Hui-Jun,Zhang, Xiang,Gao, Yong-Xin,Li, Jian-Zhong,Wang, Hui-Li. "Design, synthesis, and antifungal activities of new β-methoxyacrylate analogues". . p. 27 - 34. Retrieved 2013/08/24.