11β,16α-dihydroxyandrosta-1,4-diene-3,17-dione

Base Information

• Chemical Name: 11β,16α-dihydroxyandrosta-1,4-diene-3,17-dione
• CAS No.: 910299-74-0
• Molecular Formula: C₁₉H₂₄O₄
• Molecular Weight: 316.397
• Mol file: 910299-74-0.mol

Synonyms:

Chemical Property of 11β,16α-dihydroxyandrosta-1,4-diene-3,17-dione

Chemical Property:

• Boiling Point: 524.9±50.0 °C(Predicted)
• Density: 1.29±0.1 g/cm3(Predicted)

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

(11β,16α)-11,16-Dihydroxyandrosta-1,4-diene-3,17-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (11β,16α)-11,16-Dihydroxyandrosta-1,4-diene-3,17-dione has been identified as a budesonide tablet impurity.

Technology Process of 11β,16α-dihydroxyandrosta-1,4-diene-3,17-dione

There total 2 articles about 11β,16α-dihydroxyandrosta-1,4-diene-3,17-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

17β-hydroperoxy-11β-hydroxy-16α,17α-(1-methylethylidenedioxy)androsta-1,4-diene-3-one → 11β,16α-dihydroxyandrosta-1,4-diene-3,17-dione (910299-74-0)

Guidance literature:

With triphenylphosphine; In dichloromethane; for 2h;

DOI:10.1248/cpb.54.836

Reference yield:

desonide (638-94-8) → 11β,16α-dihydroxyandrosta-1,4-diene-3,17-dione (910299-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / oxygen / acetonitrile / 2.5 h / UV-irradiation

2: 15 mg / triphenylphosphine / CH₂Cl₂ / 2 h

With oxygen; triphenylphosphine; In dichloromethane; acetonitrile;

DOI:10.1248/cpb.54.836

upstream raw materials:

desonide

Refernces