(+/-)-{4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}[2-(3-hydroxybutyl)benzofuran-3-yl]methanone hydrochloride

Base Information

• Chemical Name: (+/-)-{4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}[2-(3-hydroxybutyl)benzofuran-3-yl]methanone hydrochloride
• CAS No.: 516508-80-8
• Molecular Formula: C₂₅H₂₉I₂NO₄*ClH
• Molecular Weight: 697.779
• Mol file: 516508-80-8.mol

Synonyms:

Chemical Property of (+/-)-{4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}[2-(3-hydroxybutyl)benzofuran-3-yl]methanone hydrochloride

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

3’-Hydroxy-amiodaroneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3’-Hydroxy-amiodarone Hydrochloride is a metabolite of the drug Amiodarone Hydrochloride (A632950), which is a non-selective ion channel blocker. Antiarrhythmic (class III).Also, it is derived from 4-Pentyn-1-ol (P227540), which is an alkyne alcohol that is used as an initiator in ring-opening polymerization reactions. 4-Pentyn-1-ol is capable of undergoing cyclosisomerization, and is also used as a reactant in the synthesis of (+)-Serinolamide A, a cannabinoid CB1 receptor agonist.

Technology Process of (+/-)-{4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}[2-(3-hydroxybutyl)benzofuran-3-yl]methanone hydrochloride

There total 1 articles about (+/-)-{4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}[2-(3-hydroxybutyl)benzofuran-3-yl]methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

amiodarone hydrochloride (19774-82-4) → 4-Hydroxyamiodarone (1355969-25-3) + (+/-)-{4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}[2-(3-hydroxybutyl)benzofuran-3-yl]methanone hydrochloride (516508-80-8)

Guidance literature:

With CYP₂J₂ supersomes; NADPH; magnesium chloride; at 37 ℃; for 1h; pH=7.4; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1124/dmd.111.043505

upstream raw materials:

amiodarone hydrochloride

Refernces