(+/-)-cis-3-methoxy-cyclopentanecarboxylic acid p-toluidide

Base Information

• Chemical Name: (+/-)-cis-3-methoxy-cyclopentanecarboxylic acid p-toluidide
• CAS No.: 109646-10-8
• Molecular Formula: C₁₄H₁₉NO₂
• Molecular Weight: 233.31
• Mol file: 109646-10-8.mol

Synonyms:

Chemical Property of (+/-)-cis-3-methoxy-cyclopentanecarboxylic acid p-toluidide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-cis-3-methoxy-cyclopentanecarboxylic acid p-toluidide

There total 3 articles about (+/-)-cis-3-methoxy-cyclopentanecarboxylic acid p-toluidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-oxocyclopentane-1-carboxylate (32811-75-9) → (+/-)-cis-3-methoxy-cyclopentanecarboxylic acid p-toluidide (109646-10-8)

Guidance literature:

Multi-step reaction with 4 steps

1: Raney nickel; ethanol / Hydrogenation

2: aqueous NaOH / Hydrolysis

3: Ag₂O / Erhitzen des Reaktionsprodukts mit wss. NaOH

With sodium hydroxide; ethanol; nickel; silver(l) oxide;

DOI:10.1021/jo01087a616

Reference yield:

3-hydroxycyclopentanecarboxylic acid methyl ester (32811-76-0,1292307-06-2) → (+/-)-cis-3-methoxy-cyclopentanecarboxylic acid p-toluidide (109646-10-8)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous NaOH / Hydrolysis

2: Ag₂O / Erhitzen des Reaktionsprodukts mit wss. NaOH

With sodium hydroxide; silver(l) oxide;

DOI:10.1021/jo01087a616

Reference yield:

(+/-)-cis-3-methoxy-cyclopentanecarboxylic acid (102539-67-3) + p-toluidine (106-49-0,12221-03-3) → (+/-)-cis-3-methoxy-cyclopentanecarboxylic acid p-toluidide (109646-10-8)

Guidance literature:

DOI:10.1021/jo01087a616

upstream raw materials:

(+/-)-cis-3-methoxy-cyclopentanecarboxylic acid

p-toluidine

methyl 3-oxocyclopentane-1-carboxylate

3-hydroxycyclopentanecarboxylic acid methyl ester