4-hydroxy-5-methoxy-isophthalaldehyde-bis-(2-methyl-isonicotinoylhydrazone)

Base Information

• Chemical Name: 4-hydroxy-5-methoxy-isophthalaldehyde-bis-(2-methyl-isonicotinoylhydrazone)
• CAS No.: 122472-76-8
• Molecular Formula: C₂₃H₂₂N₆O₄
• Molecular Weight: 446.465
• Mol file: 122472-76-8.mol

Synonyms:

Chemical Property of 4-hydroxy-5-methoxy-isophthalaldehyde-bis-(2-methyl-isonicotinoylhydrazone)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxy-5-methoxy-isophthalaldehyde-bis-(2-methyl-isonicotinoylhydrazone)

There total 4 articles about 4-hydroxy-5-methoxy-isophthalaldehyde-bis-(2-methyl-isonicotinoylhydrazone) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-methylisonicotinate (16830-24-3) → 4-hydroxy-5-methoxy-isophthalaldehyde-bis-(2-methyl-isonicotinoylhydrazone) (122472-76-8)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; N₂H₄+H₂O

2: aqueous ethanol

With methanol; ethanol; hydrazine hydrate;

DOI:10.1002/hlca.19550380425

Reference yield:

2-hydroxy-6-methylpyridine-4-carboxylic acid (86454-13-9) → 4-hydroxy-5-methoxy-isophthalaldehyde-bis-(2-methyl-isonicotinoylhydrazone) (122472-76-8)

Guidance literature:

Multi-step reaction with 4 steps

1: POCl₃; PCl₅ / Behandeln des Reaktionsprodukts mit Methanol

2: palladium/charcoal; methanol; potassium acetate / Hydrogenation

3: methanol; N₂H₄+H₂O

4: aqueous ethanol

With methanol; palladium on activated charcoal; ethanol; phosphorus pentachloride; potassium acetate; hydrazine hydrate; trichlorophosphate;

DOI:10.1002/hlca.19550380425

Reference yield:

2-chloro-6-methyl-isonicotinic acid methyl ester (3998-90-1) → 4-hydroxy-5-methoxy-isophthalaldehyde-bis-(2-methyl-isonicotinoylhydrazone) (122472-76-8)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium/charcoal; methanol; potassium acetate / Hydrogenation

2: methanol; N₂H₄+H₂O

3: aqueous ethanol

With methanol; palladium on activated charcoal; ethanol; potassium acetate; hydrazine hydrate;

DOI:10.1002/hlca.19550380425

upstream raw materials:

2-methylisonicotinohydrazide

5-formylvanillin

2-hydroxy-6-methylpyridine-4-carboxylic acid

methyl 2-methylisonicotinate