4-Pyridinecarboxylic acid, 2-methyl-, hydrazide

Base Information

• Chemical Name: 4-Pyridinecarboxylic acid, 2-methyl-, hydrazide
• CAS No.: 3758-59-6
• Molecular Formula: C7H9 N3 O
• Molecular Weight: 151.168
• Hs Code.: 2933399090
• Mol file: 3758-59-6.mol

Synonyms:Isonicotinicacid, 2-methyl-, hydrazide (6CI,7CI,8CI); 2-Methylisonicotinic acid hydrazide;2-Methylisonicotinoylhydrazine; NSC 280609

Chemical Property of 4-Pyridinecarboxylic acid, 2-methyl-, hydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 68.01000
• Density: 1.195g/cm³
• LogP: 1.08470

Purity/Quality:

99%, ^*data from raw suppliers

2-Methylisonicotinohydrazidehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyridinecarboxylic acid, 2-methyl-, hydrazide

There total 7 articles about 4-Pyridinecarboxylic acid, 2-methyl-, hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-methylisonicotinic acid (4021-11-8) → 2-methylisonicotinohydrazide (3758-59-6)

Guidance literature:

2-methylisonicotinic acid; With triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; In N,N-dimethyl-formamide; at 23 ℃; for 0.25h;

With hydrazine hydrate; In N,N-dimethyl-formamide; at 23 ℃; for 1.08333h; Cooling with ice;

DOI:10.1016/j.tube.2021.102100

Reference yield: 88.0%

→ 2-methylisonicotinohydrazide (3758-59-6)

Guidance literature:

Reference yield: 86.0%

methyl 2-methylisonicotinate (16830-24-3) → 2-methylisonicotinohydrazide (3758-59-6)

Guidance literature:

With hydrazine; In methanol; at 20 ℃; for 18h;

upstream raw materials:

methyl 2-methylisonicotinate

2-chloro-6-methylisonicotinohydrazide

2-hydroxy-6-methylpyridine-4-carboxylic acid

2-chloro-6-methyl-isonicotinic acid methyl ester

Downstream raw materials:

4-hydroxy-5-methoxy-isophthalaldehyde-bis-(2-methyl-isonicotinoylhydrazone)

2-methyl-isonicotinic acid-(4-nitro-benzylidenehydrazide)

2-methyl-isonicotinic acid-(4-acetylamino-benzylidenehydrazide)

2-methyl-isonicotinic acid benzylidenehydrazide

Refernces

• 1、 -. "3. 6 - Disubstituted [1, 2, 4] triazolo [3, 4 - b] [1, 3, 4] thiadiazole compound and use thereof". Paragraph 0070. . Retrieved 2018/11/22.
• 2、 Sato, Takahiro,Ashizawa, Naoki,Matsumoto, Koji,Iwanaga, Takashi,Nakamura, Hiroshi,Inoue, Tsutomu,Nagata, Osamu. "Discovery of 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051-a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia". experimental part. p. 6225 - 6229. Retrieved 2010/07/02.