N-hydroxy-1,1-bis(4-methoxyphenyl)methanimine

Base Information

• Chemical Name: N-hydroxy-1,1-bis(4-methoxyphenyl)methanimine
• CAS No.: 54150-63-9
• Molecular Formula: C15H15 N O3
• Molecular Weight: 257.289
• Mol file: 54150-63-9.mol

Synonyms:4,4'-Dimethoxybenzophenoneoxime; NSC 151921

Chemical Property of N-hydroxy-1,1-bis(4-methoxyphenyl)methanimine

Chemical Property:

• Vapor Pressure: 1.94E-07mmHg at 25°C
• Boiling Point: 409.5°C at 760 mmHg
• Flash Point: 201.4°C
• Density: 1.11g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-hydroxy-1,1-bis(4-methoxyphenyl)methanimine

There total 6 articles about N-hydroxy-1,1-bis(4-methoxyphenyl)methanimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

bis(p-methoxyphenyl)methanone (90-96-0) → 4,4'-dimethoxybenzophenone oxime (54150-63-9)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol; at 70 - 80 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b01242

Reference yield:

2-tert-Butyl-3,3-bis-(4-methoxy-phenyl)-oxaziridine → 4,4'-dimethoxybenzophenone oxime (54150-63-9) + isobutene (115-11-7,15220-85-6)

Guidance literature:

In ⁽²⁾H₈-toluene; at 95 ℃; Product distribution; Rate constant; Thermodynamic data; k = 8.54E-4/sec, ΔG^* = 26.8 kcal/mol;

DOI:10.1016/S0040-4039(01)80234-3

Reference yield:

methoxybenzene (100-66-3) → 4,4'-dimethoxybenzophenone oxime (54150-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃ / nach 3-4 stdn. Giessen in Eiswasser

2: hydroxylamine

With aluminium trichloride; hydroxylamine;

DOI:10.1111/j.1945-5100.2001.tb01868.x

upstream raw materials:

bis(p-methoxyphenyl)methanone

bis(4-methoxyphenyl)thione

4-methoxy-benzoyl chloride

methoxybenzene

Downstream raw materials:

4-methoxy-N-(4-methoxyphenyl)benzamide

p,p'-dimethoxybenzhydrylamine

bis(p-methoxyphenyl)methanone

Methyl--aminoxid

Refernces

• 1、 Xu, Jiaxi,Gao, Yu,Li, Zhenjiang,Liu, Jingjing,Guo, Tianfo,Zhang, Lei,Wang, Haixin,Zhang, Zhihao,Guo, Kai. "Chlorotropylium Promoted Conversions of Oximes to Amides and Nitriles". . p. 311 - 315. Retrieved 2020/01/25.
• 2、 Zhang, Wenwen,Yang, Shiwei,Lin, Qiuyu,Cheng, Heyong,Liu, Jinhua. "Microdroplets as Microreactors for Fast Synthesis of Ketoximes and Amides". . p. 851 - 859. Retrieved 2019/01/24.