4,4'-Dimethoxybenzhydrylamine

Base Information

• Chemical Name: 4,4'-Dimethoxybenzhydrylamine
• CAS No.: 19293-62-0
• Molecular Formula: C15H17NO2
• Molecular Weight: 243.305
• Hs Code.: 2922299090
• European Community (EC) Number: 678-146-5
• NSC Number: 505712
• DSSTox Substance ID: DTXSID90325411
• Nikkaji Number: J382.982K
• Wikidata: Q82085781
• Mol file: 19293-62-0.mol

Synonyms:19293-62-0;4,4'-Dimethoxybenzhydrylamine;bis(4-methoxyphenyl)methanamine;1,1-Di(p-anisyl)methylamine;1,1-bis(4-methoxyphenyl)methanamine;4,4/'-DIMETHOXYBENZHYDRYLAMINE;[bis(4-methoxyphenyl)methyl]amine;NSC505712;SCHEMBL114318;DTXSID90325411;4,4'-dimethoxy-diphenylmethylamine;1,1-Bis(4-methoxyphenyl)methanami;MFCD00191409;STK260090;C(N)(c1ccc(OC)cc1)c2ccc(OC)cc2;AKOS000164331;C,C-bis-(4-methoxyphenyl)-methylamine;NSC 505712;NSC-505712;C,C-Bis-(4-methoxy-phenyl)-methylamine;AS-37811;SRI-11160-02;Bis(4-methoxyphenyl)methanamine, AldrichCPR;BB 0237307;CS-0172578;FT-0737095;EN300-49197;A880298

Chemical Property of 4,4'-Dimethoxybenzhydrylamine

Chemical Property:

• Melting Point: 62 °C
• Boiling Point: 386 °C at 760 mmHg
• PKA: 8.85±0.10(Predicted)
• Flash Point: 187.2 °C
• PSA: 44.48000
• Density: 1.099 g/cm³
• LogP: 3.45220
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: soluble in Methanol
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 243.125928785
• Heavy Atom Count: 18
• Complexity: 207

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,4''-Dimethoxybenzhydrylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,N
• Statements: 36/37/38-50
• Safety Statements: 26-36/37/39-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)N

Technology Process of 4,4'-Dimethoxybenzhydrylamine

There total 22 articles about 4,4'-Dimethoxybenzhydrylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4,4'-dimethoxydiphenylmethyl chloride (7525-23-7) → p,p'-dimethoxybenzhydrylamine (19293-62-0)

Guidance literature:

With ammonia; In chloroform; for 2h;

DOI:10.1021/jm00143a008

Reference yield: 100.0%

phenyl N-(4,4'-dimethoxybenzhydryl)carbamate → p,p'-dimethoxybenzhydrylamine (19293-62-0)

Guidance literature:

With lithium hydroxide; water; In acetonitrile; at 50 ℃; for 3h;

DOI:10.1055/s-2000-6391

Reference yield: 94.0%

bis(4-methoxyphenyl)methanimine (5291-48-5) → p,p'-dimethoxybenzhydrylamine (19293-62-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 2h;

DOI:10.1055/s-2002-19328

upstream raw materials:

4,4'-dimethoxybenzophenone oxime

4,4'-dimethoxydiphenylmethyl chloride

bis(4-methoxyphenyl)methanone O-methyl oxime

N-[bis(4-methoxyphenyl)methyl]-formamide

Downstream raw materials:

[Bis-(4-methoxy-phenyl)-methyl]-[(E)-3-phenyl-prop-2-en-(E)-ylidene]-amine

N-(1-Cyano-2-fluoroallyl)-4,4'-dimethoxybenzhydrylamine

(3S,4S)-4-<(S)-1-benzyloxyethyl>-1--3-<(S)-1-hydroxyethyl>-2-azetidinone

(3S,4S)-4-<(S)-1-benzyloxyethyl>-1--3-<(R)-1-hydroxyethyl>-2-azetidinone

Refernces

• 1、 Babu, K. Naresh,Masarwa, Ahmad,Massarwe, Fedaa,Shioukhi, Israa. "Sequential Selective C?H and C(sp3)?+P Bond Functionalizations: An Entry to Bioactive Arylated Scaffolds". . p. 26199 - 26209. Retrieved 2021/11/09.
• 2、 Hurtley, Anna E.,Stone, Elizabeth A.,Metrano, Anthony J.,Miller, Scott J.. "Desymmetrization of Diarylmethylamido Bis(phenols) through Peptide-Catalyzed Bromination: Enantiodivergence as a Consequence of a 2 amu Alteration at an Achiral Residue within the Catalyst". supporting information. p. 11326 - 11336. Retrieved 2017/11/10.