2-Butoxyethylamine

Base Information

• Chemical Name: 2-Butoxyethylamine
• CAS No.: 6338-52-9
• Molecular Formula: C6H15 N O
• Molecular Weight: 117.191
• Hs Code.: 2922199090
• European Community (EC) Number: 228-728-6
• NSC Number: 40757
• UNII: UGV493Z3RE
• DSSTox Substance ID: DTXSID80212785
• Nikkaji Number: J206.940G
• Wikidata: Q83087985
• Mol file: 6338-52-9.mol

Synonyms:2-Butoxyethylamine;2-butoxyethanamine;6338-52-9;2-butoxyethan-1-amine;(2-BUTOXYETHYL)AMINE HYDROCHLORIDE;EINECS 228-728-6;NSC-40757;Ethanamine, 2-butoxy-;NSC40757;2-Butoxy-ethylamine;Ethylamine, 2-butoxy-;2-Butoxy-1-aminoethane;UGV493Z3RE;SCHEMBL309204;DTXSID80212785;NSC 40757;AKOS005173361;BB 0258339;CS-0454484;FT-0683112;EN300-51839;F79505;Z409191398

Chemical Property of 2-Butoxyethylamine

Chemical Property:

• Vapor Pressure: 2.64mmHg at 25°C
• Boiling Point: 158.3°C at 760 mmHg
• Flash Point: 43°C
• PSA: 35.25000
• Density: 0.851g/cm³
• LogP: 1.46210
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 117.115364102
• Heavy Atom Count: 8
• Complexity: 39.5

Purity/Quality:

98%min ^*data from raw suppliers

(2-Butoxyethyl)amine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCOCCN

Technology Process of 2-Butoxyethylamine

There total 11 articles about 2-Butoxyethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-(2-butoxy-ethyl)-phthalimide (56058-19-6) → 2-butoxyethylamine (6338-52-9)

Guidance literature:

With hydrazine hydrate; In methanol; water; at 60 ℃; for 0.5h;

DOI:10.1021/jacs.8b06881

Reference yield: 74.8%

bis-(2-butoxy-ethyl)-amine (6250-98-2) → 2-butoxyethylamine (6338-52-9)

Guidance literature:

Reference yield:

-butyl vinyl ether (111-34-2,92680-80-3) → 2-butoxyethylamine (6338-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethyl phosphite; 2,2'-azobis(isobutyronitrile) / benzene / 12 h / 90 °C

2: hydrazine hydrate / water; methanol / 0.5 h / 60 °C

With 2,2'-azobis(isobutyronitrile); hydrazine hydrate; triethyl phosphite; In methanol; water; benzene;

DOI:10.1021/jacs.8b06881

upstream raw materials:

O-butyl-lactic acid amide

2-Butoxyethanol

butoxyacetonitrile

ethyleneimine

Downstream raw materials:

2-<<5-<(2-butoxyethyl)amino>pentyl>thio>-4,5-diphenyl-1H-imidazole

N-(2-butoxyethyl)-5-<(4,5-diphenyl-1H-imidazol-2-yl)thio>pentanamide

1-(2-butoxyethyl)-4-phenyl-4-imidazolin-2-one

1-(2-butoxyethyl)-4-phenyl-2-imidazolidone

Refernces

• 1、 Lardy, Samuel W.,Schmidt, Valerie A.. "Intermolecular Radical Mediated Anti-Markovnikov Alkene Hydroamination Using N-Hydroxyphthalimide". supporting information. p. 12318 - 12322. Retrieved 2018/10/02.
• 2、 -. "Catalytic process for the production of primary amines from oxyethylene glycol monoalkyl ethers". . . Retrieved 2008/06/13.