4-(4-PYRIDINYL)BENZONITRILE

Base Information

• Chemical Name: 4-(4-PYRIDINYL)BENZONITRILE
• CAS No.: 144397-70-6
• Molecular Formula: C12H8N2
• Molecular Weight: 180.209
• Hs Code.: 2933399090
• Mol file: 144397-70-6.mol

Synonyms:4-pyridin-4-ylbenzonitrile;4-pyridin-4-yl-benzonitrile;4-(4-Pyridyl)benzonitrile;4-(Pyridine-4-yl)benzonitrile;4-(Pyridin-4-yl)benzonitrile;p-(4-pyridinyl)benzonitrile;

Chemical Property of 4-(4-PYRIDINYL)BENZONITRILE

Chemical Property:

• PSA: 36.68000
• LogP: 2.62028

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-(Pyridin-4-yl)benzonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-PYRIDINYL)BENZONITRILE

There total 15 articles about 4-(4-PYRIDINYL)BENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-Cyanochlorobenzene (623-03-0) + potassium (pyridin-4-yl)trifluoroborate → 4-(pyridin-4-yl)benzonitrile (144397-70-6)

Guidance literature:

With palladium diacetate; sodium carbonate; ruphos; In ethanol; at 85 ℃; Inert atmosphere;

DOI:10.1021/jo802590b

Reference yield: 90.0%

4-iodobenzonitrile (3058-39-7) + triphenyl(pyridin-4-yl)phosphonium trifluoromethanesulfonate (113964-72-0) → 4-(pyridin-4-yl)benzonitrile (144397-70-6)

Guidance literature:

With palladium diacetate; silver perchlorate; potassium carbonate; ruphos; In acetone; at 65 ℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.202006724

Reference yield: 90.0%

4-bromobenzenecarbonitrile (623-00-7) + 4-pyridylboronic acid (1692-15-5) → 4-(pyridin-4-yl)benzonitrile (144397-70-6)

Guidance literature:

With tetra-butylammonium acetate; Pd EnCat-30^TM; In ethanol; at 120 ℃; for 0.166667h; microwave irradiation;

DOI:10.1002/chem.200501400

upstream raw materials:

4-Cyanochlorobenzene

4-pyridylboronic acid

4-bromobenzenecarbonitrile

pyridine

Downstream raw materials:

4-(3-chloro-phenylamino)-3-[4-(pyrid-4-yl)-benzylamino]-1H-pyrazolo[3,4-d]pyrimidine

4-(1,2,3,6-tetrahydropyridin-4-yl)benzonitrile

4-(pyridin-4-yl)-benzylamine

7-chloro-2-ethyl-N-[4-(pyridin-4-yl)benzyl]imidazo[1,2-a]pyridine-3-carboxamide

Refernces

• 1、 Che, Yuan-Yuan,Deng, Xuezu,Feng, Chao,Lin, Ling-Zhi,Pei, Bingbing,Yue, Yanni. "Palladium-Catalyzed Electrophilic Functionalization of Pyridine Derivatives through Phosphonium Salts". supporting information. p. 16414 - 16419. Retrieved 2020/07/20.
• 2、 Salamanca, Vanesa,Toledo, Alberto,Albéniz, Ana C.. "[2,2′-bipyridin]-6(1 H)-one, a Truly Cooperating Ligand in the Palladium-Mediated C-H Activation Step: Experimental Evidence in the Direct C-3 Arylation of Pyridine". supporting information. p. 17851 - 17856. Retrieved 2019/01/04.