BENZOIC ACID,4-(2-PHENYLETHYL)-,METHYL ESTER

Base Information

• Chemical Name: BENZOIC ACID,4-(2-PHENYLETHYL)-,METHYL ESTER
• CAS No.: 14518-67-3
• Molecular Formula: C16H16O2
• Molecular Weight: 240.302
• Mol file: 14518-67-3.mol

Synonyms:4-phenethyl-benzoic acid methyl ester;4-phenethylbenzoic acid methyl ester;BENZOIC ACID,4-(2-PHENYLETHYL)-,METHYL ESTER;

Chemical Property of BENZOIC ACID,4-(2-PHENYLETHYL)-,METHYL ESTER

Chemical Property:

• PSA: 26.30000
• LogP: 3.25840

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZOIC ACID,4-(2-PHENYLETHYL)-,METHYL ESTER

There total 18 articles about BENZOIC ACID,4-(2-PHENYLETHYL)-,METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(4-methoxycarbonylphenyl)-2-phenylethene (46925-32-0) → methyl 4-(phenylethyl)benzoate (14518-67-3)

Guidance literature:

With 1-Benzyl-1,4-dihydronicotinamide; tris(2,2’-bipyridine)ruthenium(II); In pyridine; methanol; for 1h; Irradiation;

DOI:10.1021/jo00175a006

Reference yield: 92.0%

methyl 4-(phenylethynyl)benzoate (42497-80-3) → methyl 4-(phenylethyl)benzoate (14518-67-3)

Guidance literature:

With iron(III) chloride; lithium aluminium tetrahydride; hydrogen; In tetrahydrofuran; at 18 ℃; for 20h; under 750.075 Torr; Inert atmosphere; Sealed tube;

DOI:10.1039/c4gc02368d

Reference yield: 87.0%

methyl 4-iodobenzoate (619-44-3) + phenylpropionic acid sodium salt (114-84-1) → methyl 4-(phenylethyl)benzoate (14518-67-3)

Guidance literature:

phenylpropionic acid sodium salt; With N-hydroxyphthalimide tetramethyluronium hexafluorphosphate; In N,N-dimethyl acetamide; at 20 ℃;

methyl 4-iodobenzoate; With (1,2-dimethoxyethane)dichloronickel(II); 4,4'-di-tert-butyl-2,2'-bipyridine; sodium iodide; In N,N-dimethyl acetamide; at 20 ℃;

DOI:10.1021/acs.orglett.8b04090

upstream raw materials:

1-(4-methoxycarbonylphenyl)-2-phenylethene

(E)-methyl 4-styrylbenzoate

4-methoxycarbonylbenzyltriphenylphosphonium bromide

benzaldehyde

Downstream raw materials:

1-(bromomethyl)-4-phenethylbenzene

methyl 4-(((5-methoxy-5-oxopentyl)(2-((4-phenethylbenzyl)oxy)phenethyl)amino)methyl)benzoate

4-[[(4-carboxybutyl)-[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid hydrochloride

3-(phenylethyl)benzoic acid

Refernces

• 1、 Zubar, Viktoriia,Sklyaruk, Jan,Brzozowska, Aleksandra,Rueping, Magnus. "Chemoselective Hydrogenation of Alkynes to (Z) -Alkenes Using an Air-Stable Base Metal Catalyst". supporting information. p. 5423 - 5428. Retrieved 2020/07/24.
• 2、 Nguyen, Julia,Chong, Andrea,Lalic, Gojko. "Nickel-catalyzed anti-Markovnikov hydroarylation of alkenes". . p. 3231 - 3236. Retrieved 2019/03/21.